Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UTS2R | Q9UKP6 | 19/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | HTR2C | P28335 | 1/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.48 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5547240 | 0.87 | UTS2R (0.46) | UTS2RADRA2ADRD2SLC6A2HTR2A | |
| SCHEMBL3560401 | 0.84 | UTS2R (0.57) | UTS2RADRA2ADRD2SLC6A2HTR2A | |
| SCHEMBL5541293 | 0.83 | UTS2R (0.45) | UTS2RADRA2ADRD2SLC6A2HTR2A | |
| SCHEMBL5547628 | 0.81 | UTS2R (0.48) | UTS2RADRA2ADRD2SLC6A2HTR2A | |
| SCHEMBL5547260 | 0.81 | UTS2R (0.50) | UTS2RADRA2ADRD2SLC6A2HTR2A | |
| SCHEMBL3565146 | 0.80 | UTS2R (0.63) | UTS2RADRA2ADRD2SLC6A2HTR2A | |
| SCHEMBL3563302 | 0.75 | UTS2R (0.68) | UTS2RADRA2ADRD2SLC6A2HTR2A | |
| SCHEMBL3559983 | 0.75 | UTS2R (0.75) | UTS2RADRA2ADRD2SLC6A2HTR2A | |
| SCHEMBL3557619 | 0.75 | UTS2R (0.44) | UTS2RADRA2ADRD2SLC6A2HTR2A | |
| SCHEMBL3557622 | 0.75 | UTS2R (0.44) | UTS2RADRA2ADRD2SLC6A2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4851328-B2 | — | — | 2012-01-11 | — | — | JP | claimed |
| JP-2007506692-A | — | — | 2007-03-22 | — | — | JP | claimed |
| EP-1670470-A1 | PYRIDINE DERIVATIVES AND USE THEREOF AS UROTENSIN II ANTAGONISTS | Actelion Pharmaceuticals Ltd. (CH) | 2006-06-21 | — | — | EP | claimed |
| WO-2005030209-A1 | PYRIDINE DERIVATIVES AND USE THEREOF AS UROTENSIN II ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2005-04-07 | — | — | WO | claimed |