Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.59 |
| ▸ | PIM1 | P11309 | 5/20 | 0.39 |
| ▸ | PIM2 | Q9P1W9 | 4/20 | 0.39 |
| ▸ | JAK2 | O60674 | 2/20 | 0.38 |
| ▸ | JAK3 | P52333 | 2/20 | 0.38 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.37 |
| ▸ | SMPD3 | Q9NY59 | 3/20 | 0.36 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.36 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.36 |
| ▸ | FYN | P06241 | 1/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.35 |
| ▸ | PDCD1LG2 | Q9BQ51 | 1/20 | 0.35 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29398488 | 0.85 | AAK1 (0.67) | AAK1PIM1PIM2JAK2JAK3 | |
| SCHEMBL17495348 | 0.85 | AAK1 (0.67) | AAK1PIM1PIM2JAK2JAK3 | |
| SCHEMBL30172444 | 0.82 | AAK1 (0.61) | AAK1JAK2JAK3PTK2 | |
| Hydrochloric Acid SCHEMBL30172437 | 0.80 | AAK1 (0.57) | AAK1PIM1PIM2JAK2JAK3 | |
| SCHEMBL30172469 | 0.80 | AAK1 (0.61) | AAK1PIM1PIM2JAK2JAK3 | |
| SCHEMBL30172443 | 0.79 | AAK1 (0.58) | AAK1PIM1PIM2JAK2JAK3 | |
| SCHEMBL30172448 | 0.79 | AAK1 (0.58) | AAK1PIM1PIM2JAK2JAK3 | |
| SCHEMBL20081012 | 0.78 | AAK1 (0.69) | AAK1PIM1PIM2JAK2JAK3 | |
| SCHEMBL20081020 | 0.77 | AAK1 (0.80) | AAK1PIM1PIM2JAK2JAK3 | |
| SCHEMBL19467027 | 0.77 | AAK1 (0.83) | AAK1PIM1PIM2JAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115677705-A | AAK1 inhibitor and application thereof | 武汉人福创新药物研发中心有限公司 | 2023-02-03 | — | — | CN | disclosed |