Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 5/20 | 0.50 |
| ▸ | YTHDC1 | Q96MU7 | 3/20 | 0.47 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.37 |
| ▸ | CDK2 | P24941 | 2/20 | 0.37 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.37 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4378141 | 1.00 | CDK1 (0.50) | CDK1YTHDC1PDE4APDE4BPDE4C | |
| SCHEMBL183035 | 0.81 | CDK1 (0.68) | CDK1YTHDC1PDE4APDE4BPDE4C | |
| SCHEMBL29426225 | 0.81 | CDK1 (0.68) | CDK1YTHDC1PDE4APDE4BPDE4C | |
| SCHEMBL7289687 | 0.79 | CDK1 (0.51) | CDK1YTHDC1PDE4APDE4BPDE4C | |
| SCHEMBL23027205 | 0.78 | CDK1 (0.42) | CDK1YTHDC1PDE4APDE4BPDE4C | |
| SCHEMBL130527 | 0.78 | CDK1 (0.64) | CDK1YTHDC1PDE4APDE4BPDE4C | |
| SCHEMBL764036 | 0.78 | CDK1 (0.59) | CDK1YTHDC1ADORA2AADORA1CCNE1 | |
| SCHEMBL380974 | 0.78 | CDK1 (0.50) | CDK1YTHDC1PDE4APDE4BPDE4C | |
| SCHEMBL8510719 | 0.77 | PDE4A (0.63) | CDK1YTHDC1PDE4APDE4BPDE4C | |
| SCHEMBL1293109 | 0.77 | CDK2 (0.49) | CDK1ADORA2AADORA1CCNE1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4380937-A1 | CONJUGATES COMPRISING COVALENT BINDERS FOR TARGETING INTRACELLULAR PROTEINS | Rayzebio, Inc. (US) | 2024-06-12 | — | — | EP | disclosed |
| WO-2023014988-A1 | CONJUGATES COMPRISING COVALENT BINDERS FOR TARGETING INTRACELLULAR PROTEINS | RAYZEBIO, INC. (US) | 2023-02-09 | — | — | WO | disclosed |