Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Sr-13668. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.64 |
| ▸ | MAPT | P10636 | 6/20 | 0.64 |
| ▸ | MEN1 | O00255 | 4/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.64 |
| ▸ | RAB9A | P51151 | 3/20 | 0.64 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.59 |
| ▸ | HPGD | P15428 | 5/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.59 |
| ▸ | POLB | P06746 | 2/20 | 0.59 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.52 |
| ▸ | TUBB | P07437 | 2/20 | 0.52 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.52 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.52 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.52 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.52 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sr-13668 SCHEMBL29381258 | 1.00 | KDM4E (0.64) | KDM4EALDH1A1MAPTMEN1KMT2A | |
| Sr-13668 SCHEMBL1071997 | 1.00 | KDM4E (0.64) | KDM4EALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL12642105 | 0.95 | KDM4E (0.58) | KDM4EALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL18705463 | 0.94 | KDM4E (0.57) | KDM4EALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL3199051 | 0.90 | KDM4E (0.64) | KDM4EALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL3187981 | 0.88 | HCRTR1 (0.70) | KDM4EALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL1120941 | 0.87 | KDM4E (0.61) | KDM4EALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL3197990 | 0.86 | KDM4E (0.67) | KDM4EALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL12968290 | 0.86 | KDM4E (0.67) | KDM4EALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL13535329 | 0.86 | KDM4E (0.60) | KDM4EALDH1A1MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119185322-A | Tetracyclic quinolone analog combination therapies for treating cancer | 生华生物科技股份有限公司 | 2024-12-27 | — | — | CN | disclosed |
| CN-119119296-A | Allogeneic cell compositions and methods of use | 波赛达治疗公司 | 2024-12-13 | — | — | CN | disclosed |
| CN-113383018-B | Allogeneic cell compositions and methods of use | 波赛达治疗公司 | 2024-09-10 | — | — | CN | disclosed |
| CN-115697413-A | Radiopharmaceuticals and imaging agents targeting FAP and uses related thereto | 塔夫茨大学信托人 | 2023-02-03 | — | — | CN | disclosed |