Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | AKR1B1 | P15121 | 5/20 | 0.43 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
| ▸ | AKR1A1 | P14550 | 2/20 | 0.41 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23976545 | 1.00 | TSHR (0.44) | TSHRTDP1AKR1B1BACE1AKR1A1 | |
| SCHEMBL18150985 | 0.77 | TSHR (0.65) | TSHRTDP1AKR1B1 | |
| SCHEMBL17606364 | 0.68 | TSHR (0.60) | TSHRTDP1AKR1B1AKR1A1AKR1B10 | |
| SCHEMBL30062196 | 0.68 | TSHR (0.49) | TSHRTDP1AKR1B1 | |
| SCHEMBL23645194 | 0.68 | KDM4C (0.33) | BACE1PDE7A | |
| SCHEMBL30297506 | 0.67 | TSHR (0.55) | TSHRTDP1AKR1B1AKR1A1AKR1B10 | |
| SCHEMBL10696197 | 0.67 | AKR1B1 (0.50) | TSHRTDP1AKR1B1AKR1A1AKR1B10 | |
| SCHEMBL17605535 | 0.67 | TSHR (0.59) | TSHRTDP1AKR1B1PDE7A | |
| SCHEMBL17606416 | 0.67 | TSHR (0.59) | TSHRTDP1AKR1B1PDE7A | |
| SCHEMBL17605411 | 0.67 | TSHR (0.59) | TSHRTDP1AKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4143187-A1 | COMPOUNDS AND COMPOSITIONS FOR INHIBITING THE ACTIVITY OF HIF2-ALPHA AND THEIR METHODS OF USE | Novartis AG (CH) | 2023-03-08 | — | — | EP | disclosed |