Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 19/20 | 0.38 |
| ▸ | JAK2 | O60674 | 2/20 | 0.36 |
| ▸ | FLT3 | P36888 | 2/20 | 0.36 |
| ▸ | KIF5B | P33176 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | CCDC6 | Q16204 | 1/20 | 0.36 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29696063 | 1.00 | RET (0.38) | RETJAK2FLT3KIF5BKDR | |
| SCHEMBL28722963 | 1.00 | RET (0.38) | RETJAK2FLT3KIF5BKDR | |
| SCHEMBL29521133 | 1.00 | RET (0.38) | RETJAK2FLT3KIF5BKDR | |
| SCHEMBL23929889 | 1.00 | RET (0.38) | RETJAK2FLT3KIF5BKDR | |
| SCHEMBL18806642 | 1.00 | RET (0.38) | RETJAK2FLT3KIF5BKDR | |
| SCHEMBL23957787 | 1.00 | RET (0.38) | RETJAK2FLT3KIF5BKDR | |
| SCHEMBL17966632 | 1.00 | RET (0.38) | RETJAK2FLT3KIF5BKDR | |
| SCHEMBL18821888 | 1.00 | RET (0.38) | RETJAK2FLT3KIF5BKDR | |
| SCHEMBL17966631 | 1.00 | RET (0.38) | RETJAK2FLT3KIF5BKDR | |
| SCHEMBL26597577 | 1.00 | RET (0.38) | RETJAK2FLT3KIF5BKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113135896-B | Methylpyrazole derivatives as RET inhibitors | 正大天晴药业集团股份有限公司 | 2024-12-06 | — | — | CN | disclosed |
| CN-115605477-B | Pyrazolo [1,5-a ] pyridine derivative, preparation method, composition and application thereof | 深圳众格生物科技有限公司 | 2024-07-05 | — | — | CN | disclosed |
| CN-115605477-A | Pyrazolo [1,5-a ] pyridine derivative and preparation method, composition and application thereof | 深圳众格生物科技有限公司（CN） | 2023-01-13 | — | — | CN | disclosed |