Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR3 | Q99500 | 13/20 | 0.43 |
| ▸ | EDNRB | P24530 | 2/20 | 0.40 |
| ▸ | EDNRA | P25101 | 2/20 | 0.40 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30337659 | 1.00 | S1PR3 (0.43) | S1PR3EDNRBEDNRAPLA2G2AMEN1 | |
| SCHEMBL23886843 | 1.00 | S1PR3 (0.43) | S1PR3EDNRBEDNRAPLA2G2AMEN1 | |
| SCHEMBL30337699 | 0.92 | S1PR3 (0.42) | S1PR3EDNRBEDNRAPLA2G2AMEN1 | |
| SCHEMBL23886647 | 0.92 | S1PR3 (0.42) | S1PR3EDNRBEDNRAPLA2G2AMEN1 | |
| SCHEMBL30176330 | 0.92 | S1PR3 (0.42) | S1PR3EDNRBEDNRAPLA2G2AMEN1 | |
| SCHEMBL23887036 | 0.88 | S1PR3 (0.42) | S1PR3EDNRBEDNRAPLA2G2AMEN1 | |
| SCHEMBL30176300 | 0.88 | S1PR3 (0.42) | S1PR3EDNRBEDNRAPLA2G2AMEN1 | |
| SCHEMBL23886852 | 0.85 | S1PR3 (0.44) | S1PR3EDNRBEDNRAPLA2G2AMEN1 | |
| SCHEMBL30176254 | 0.85 | S1PR3 (0.44) | S1PR3EDNRBEDNRAPLA2G2AMEN1 | |
| SCHEMBL23886980 | 0.82 | S1PR3 (0.43) | S1PR3EDNRBEDNRAMEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4126817-A1 | SUBSTITUTED 5-HYDROXYINDOLE COMPOUNDS AS MODULATORS OF ALPHA-1 ANTITRYPSIN | Vertex Pharmaceuticals Incorporated (US) | 2023-02-08 | — | — | EP | disclosed |