Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.40 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23886735 | 1.00 | MEN1 (0.44) | MEN1KMT2AKDM4EHTTMAPT | |
| SCHEMBL30176376 | 0.83 | POLB (0.43) | MEN1KMT2AKDM4EHTTMAPT | |
| SCHEMBL23886979 | 0.83 | POLB (0.43) | MEN1KMT2AKDM4EHTTMAPT | |
| SCHEMBL30176262 | 0.78 | AKR1C3 (0.47) | MEN1KMT2AKDM4EHTTMAPT | |
| SCHEMBL23886680 | 0.78 | AKR1C3 (0.47) | MEN1KMT2AKDM4EHTTMAPT | |
| SCHEMBL23886832 | 0.75 | KDM4E (0.39) | MEN1KMT2AKDM4EHTTMAPT | |
| SCHEMBL30176358 | 0.75 | KDM4E (0.39) | MEN1KMT2AKDM4EHTTMAPT | |
| SCHEMBL23886817 | 0.72 | KDM4E (0.40) | MEN1KMT2AKDM4EHTTMAPT | |
| SCHEMBL30176370 | 0.72 | KDM4E (0.40) | MEN1KMT2AKDM4EHTTMAPT | |
| SCHEMBL23886851 | 0.69 | MEN1 (0.39) | MEN1KMT2AKDM4EHTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115916749-A | Substituted 5-hydroxyindole compounds as alpha-1 antitrypsin modulators | 弗特克斯药品有限公司 | 2023-04-04 | — | — | CN | disclosed |
| EP-4126817-A1 | SUBSTITUTED 5-HYDROXYINDOLE COMPOUNDS AS MODULATORS OF ALPHA-1 ANTITRYPSIN | Vertex Pharmaceuticals Incorporated (US) | 2023-02-08 | — | — | EP | disclosed |