Sugi Predict

Sugi Predict / Compounds / SCHEMBL30176751

SCHEMBL30176751

SCHEMBL30176751

O=c1[nH]c2cc(-c3cc(F)cc(F)c3)cnc2[nH]1

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PRKD3 O94806 2/20 0.64
▸ MAP4K4 O95819 2/20 0.64
▸ RET P07949 2/20 0.64
▸ PIM1 P11309 2/20 0.64
▸ KDR P35968 2/20 0.64
▸ GSK3A P49840 2/20 0.64
▸ GSK3B P49841 2/20 0.64
▸ RPS6KA3 P51812 2/20 0.64
▸ CDK5 Q00535 2/20 0.64
▸ MAP4K2 Q12851 2/20 0.64
▸ AURKB Q96GD4 2/20 0.64
▸ CLK4 Q9HAZ1 2/20 0.64
▸ PLK4 O00444 1/20 0.64
▸ CHEK1 O14757 1/20 0.64
▸ CDK1 P06493 1/20 0.64
▸ LYN P07948 1/20 0.64
▸ FER P16591 1/20 0.64
▸ CDK2 P24941 1/20 0.64
▸ MARK3 P27448 1/20 0.64
▸ FLT4 P35916 1/20 0.64

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30532112 0.81 PRKD3 (0.65) PRKD3MAP4K4RETPIM1KDR
SCHEMBL31425375 0.80 PRKD3 (0.61) PRKD3MAP4K4RETPIM1KDR
SCHEMBL13290171 0.80 PRKD3 (0.61) PRKD3MAP4K4RETPIM1KDR
SCHEMBL30176559 0.80 PRKD3 (0.64) PRKD3MAP4K4RETPIM1KDR
SCHEMBL2208549 0.77 PDE3B (1.00) PRKD3MAP4K4RETPIM1KDR
SCHEMBL29635977 0.76 PRKD3 (0.55) PRKD3MAP4K4RETPIM1KDR
SCHEMBL30176755 0.76 PRKD3 (0.58) PRKD3MAP4K4RETPIM1KDR
Hydrochloric Acid SCHEMBL11231961 0.75 PDE3B (0.97) PRKD3MAP4K4RETPIM1KDR
SCHEMBL30176772 0.75 PRKD3 (0.71) PRKD3MAP4K4RETPIM1KDR
SCHEMBL30532105 0.73 PIM1 (0.72) PRKD3MAP4K4RETPIM1KDR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230338341-A1 SUBSTITUTED 1H-IMIDAZO[4,5-b]PYRIDIN-2(3H)-ONES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2023-10-26 — — US disclosed
US-11759455-B2 Substituted 1H-imidazo[4,5-b]pyridin-2(3H)-ones and their use as GLUN2B receptor modulators JANSSEN PHARMACEUTICA NV (BE) 2023-09-19 — — US disclosed
US-20230000833-A1 SUBSTITUTED 1H-IMIDAZO[4,5-b]PYRIDIN-2(3H)-ONES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2023-01-05 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230000833-A1 SUBSTITUTED 1H-IMIDAZO[4,5-b]PYRIDIN-2(3H)-ONES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS GRIN2B, GRIN2A, GRIN2C PRKD3 2794/4885MAP4K4 1223/4885RET 512/4885
US-11759455-B2 Substituted 1H-imidazo[4,5-b]pyridin-2(3H)-ones and their use as GLUN2B receptor modulators GRIN2B, GRIN2A, GRIN2C PRKD3 2794/4885MAP4K4 1223/4885RET 512/4885
US-20230338341-A1 SUBSTITUTED 1H-IMIDAZO[4,5-b]PYRIDIN-2(3H)-ONES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS GRIN2B, GRIN2A, GRIN2C PRKD3 2794/4885MAP4K4 1223/4885RET 512/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.