SCHEMBL30176868

SCHEMBL30176868

O=c1[nH]c(CC2CC=CCC2)nc2ccccc12

nearest known ligand 0.56

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
TNKS2 Q9H2K2 1/20 0.52
PDE10A Q9Y233 1/20 0.52
KMT2A Q03164 4/20 0.51
PARP1 P09874 3/20 0.48
PARP2 Q9UGN5 2/20 0.48
RAB9A P51151 1/20 0.48
MEN1 O00255 3/20 0.47
POLB P06746 2/20 0.47
KDM4E B2RXH2 2/20 0.46
LMNA P02545 1/20 0.46
MAPT P10636 1/20 0.46
SMN1; SMN2 Q16637 1/20 0.45
ALDH1A1 P00352 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30176871 0.81 TNKS2 (0.57) TNKS2PDE10AKMT2APARP1PARP2
SCHEMBL25364009 0.80 TNKS2 (0.56) TNKS2PDE10AKMT2APARP1PARP2
SCHEMBL27602712 0.80 TNKS2 (0.59) TNKS2PDE10AKMT2APARP1PARP2
Hydrochloric Acid SCHEMBL6795779 0.79 TNKS2 (0.55) TNKS2PDE10AKMT2APARP1PARP2
Hydrochloric Acid SCHEMBL6795715 0.79 TNKS2 (0.57) TNKS2PDE10AKMT2APARP1PARP2
SCHEMBL16144820 0.78 TNKS2 (0.54) TNKS2PDE10AKMT2APARP1PARP2
SCHEMBL38658339 0.77 KMT2A (0.58) TNKS2PDE10AKMT2APARP1PARP2
Hydrochloric Acid SCHEMBL6796466 0.77 TNKS2 (0.52) TNKS2PDE10AKMT2APARP1PARP2
SCHEMBL7543801 0.77 PARP1 (0.55) TNKS2PDE10AKMT2APARP1PARP2
SCHEMBL25361548 0.76 PARP1 (0.54) TNKS2PDE10AKMT2APARP1PARP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112174899-B Application of light-promoted Minisci C-H alkylation reaction in preparation of alkyl-substituted azacycle 南开大学 2023-01-17 CN disclosed