Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KRAS | P01116 | 3/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 10/20 | 0.34 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.31 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.31 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.31 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21734067 | 1.00 | KRAS (0.39) | KRASGPR119C5AR1SMARCA2SMARCA4 | |
| SCHEMBL21733786 | 0.94 | KRAS (0.44) | KRASGPR119C5AR1SMARCA2SMARCA4 | |
| SCHEMBL30178124 | 0.94 | KRAS (0.44) | KRASGPR119C5AR1SMARCA2SMARCA4 | |
| SCHEMBL21733633 | 0.91 | KRAS (0.39) | KRASGPR119SMARCA2SMARCA4PBRM1 | |
| SCHEMBL30178122 | 0.91 | KRAS (0.39) | KRASGPR119SMARCA2SMARCA4PBRM1 | |
| SCHEMBL21733472 | 0.88 | KRAS (0.43) | KRASGPR119SMARCA2SMARCA4PBRM1 | |
| SCHEMBL30178032 | 0.88 | KRAS (0.43) | KRASGPR119SMARCA2SMARCA4PBRM1 | |
| SCHEMBL21734068 | 0.86 | KRAS (0.57) | KRAS | |
| SCHEMBL30177677 | 0.86 | KRAS (0.57) | KRAS | |
| SCHEMBL21734026 | 0.85 | TLR9 (0.36) | KRASGPR119KDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3746436-B1 | FUSED RING COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2026-05-20 | — | — | EP | disclosed |
| US-11760744-B2 | Fused ring compounds | GENENTECH, INC. (US) | 2023-09-19 | — | — | US | disclosed |
| US-20230002345-A1 | FUSED RING COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2023-01-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11760744-B2 | Fused ring compounds | KRAS, NRAS, HRAS | KRAS 1/4885GPR119 1771/4885C5AR1 3496/4885 |
| US-20230002345-A1 | FUSED RING COMPOUNDS | KRAS, NRAS, HRAS | KRAS 1/4885GPR119 1771/4885C5AR1 3496/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.