Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 13/20 | 1.00 |
| ▸ | FAAH | O00519 | 1/20 | 1.00 |
| ▸ | PTGS2 | P35354 | 1/20 | 1.00 |
| ▸ | SPR | P35270 | 2/20 | 0.59 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | HPGD | P15428 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.58 |
| ▸ | IDO1 | P14902 | 1/20 | 0.58 |
| ▸ | BLM | P54132 | 1/20 | 0.58 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL157036 | 1.00 | TRPV1 (1.00) | TRPV1FAAHPTGS2SPRMTNR1A | |
| SCHEMBL3810578 | 1.00 | TRPV1 (1.00) | TRPV1FAAHPTGS2SPRMTNR1A | |
| SCHEMBL1129527 | 1.00 | TRPV1 (1.00) | TRPV1FAAHPTGS2SPRMTNR1A | |
| SCHEMBL14507405 | 0.94 | TRPV1 (0.90) | TRPV1FAAHPTGS2SPRMTNR1A | |
| SCHEMBL23630280 | 0.89 | TRPV1 (1.00) | TRPV1FAAHPTGS2SPRMTNR1A | |
| SCHEMBL23630266 | 0.89 | TRPV1 (1.00) | TRPV1FAAHPTGS2SPRMTNR1A | |
| SCHEMBL23630268 | 0.89 | TRPV1 (1.00) | TRPV1FAAHPTGS2SPRMTNR1A | |
| SCHEMBL23630267 | 0.89 | TRPV1 (1.00) | TRPV1FAAHPTGS2SPRMTNR1A | |
| SCHEMBL1746356 | 0.89 | TRPV1 (1.00) | TRPV1FAAHPTGS2SPRMTNR1A | |
| SCHEMBL3815737 | 0.89 | TRPV1 (1.00) | TRPV1FAAHPTGS2SPRMTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114605385-B | Indole piperidine urea TRPV1 antagonism/FAAH inhibition double-target drug, preparation method and application | 河南大学 | 2023-09-08 | — | — | CN | disclosed |
| WO-2022230851-A1 | PROPHYLACTIC AND/OR THERAPEUTIC AGENT FOR AMYOTROPHIC LATERAL SCLEROSIS | 国立大学法人東海国立大学機構 | 2022-11-03 | — | — | WO | disclosed |