SCHEMBL30180261

SCHEMBL30180261

Cc1cc(Nc2ccc(NC(=O)c3ccc(Nc4ccnc5ccc(N6CCCCC6)cc45)nc3)cc2)ccn1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 5/20 0.44
KMT2A Q03164 4/20 0.44
USP2 O75604 2/20 0.44
DNMT1 P26358 7/20 0.43
DNMT3A Q9Y6K1 6/20 0.43
NPC1 O15118 5/20 0.43
RAB9A P51151 5/20 0.43
SMN1; SMN2 Q16637 5/20 0.43
ALDH1A1 P00352 2/20 0.43
TP53 P04637 2/20 0.43
GFER P55789 1/20 0.43
DNMT3L Q9UJW3 4/20 0.42
EHMT1 Q9H9B1 2/20 0.42
MYC P01106 1/20 0.42
MAP2K3 P46734 1/20 0.42
EHMT2 Q96KQ7 1/20 0.42
DNMT3B Q9UBC3 1/20 0.42
MEN1 O00255 3/20 0.42
KDM4E B2RXH2 1/20 0.42
LMNA P02545 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23999792 1.00 MAPT (0.44) MAPTKMT2AUSP2DNMT1DNMT3A
SCHEMBL23999637 0.99 MAPT (0.45) MAPTKMT2AUSP2DNMT1DNMT3A
SCHEMBL30180369 0.99 MAPT (0.45) MAPTKMT2AUSP2DNMT1DNMT3A
SCHEMBL30180365 0.98 MAPT (0.45) MAPTKMT2AUSP2DNMT1DNMT3A
SCHEMBL23999440 0.98 MAPT (0.45) MAPTKMT2AUSP2DNMT1DNMT3A
SCHEMBL23999438 0.92 MAPT (0.49) MAPTKMT2AUSP2NPC1RAB9A
SCHEMBL30180401 0.92 MAPT (0.49) MAPTKMT2AUSP2NPC1RAB9A
SCHEMBL23999797 0.91 MAPT (0.42) MAPTKMT2AUSP2DNMT1DNMT3A
SCHEMBL30180612 0.91 MAPT (0.42) MAPTKMT2AUSP2DNMT1DNMT3A
SCHEMBL23999697 0.90 KMT2A (0.44) MAPTKMT2AUSP2DNMT1DNMT3A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4426279-A1 AKT3 MODULATORS Georgiamune Inc. (US) 2024-09-11 EP disclosed
CN-118524833-A AKT3 modulators 乔治穆内公司 2024-08-20 CN disclosed
WO-2023081854-A1 AKT3 MODULATORS GEORGIAMUNE LLC (US) 2023-05-11 WO disclosed
CN-115867562-A AKT3 modulators 乔治穆内有限责任公司 2023-03-28 CN disclosed
EP-4146667-A1 AKT3 MODULATORS Georgiamune LLC (US) 2023-03-15 EP disclosed