SCHEMBL30180465

SCHEMBL30180465

COC(=O)c1cc(OC)c(Nc2ncc(Cl)c(Nc3ccccc3S(=O)(=O)C(C)C)n2)cc1C

nearest known ligand 0.74

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ALK Q9UM73 20/20 0.74
INSR P06213 18/20 0.74

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30180103 0.87 ALK (0.85) ALKINSR
SCHEMBL1545823 0.87 ALK (0.68) ALKINSR
SCHEMBL30180136 0.86 ALK (0.76) ALKINSR
SCHEMBL12213877 0.86 ALK (0.75) ALKINSR
SCHEMBL11916448 0.85 ALK (0.76) ALKINSR
SCHEMBL18350612 0.85 ALK (0.77) ALKINSR
SCHEMBL20085710 0.85 ALK (1.00) ALKINSR
SCHEMBL20085699 0.85 ALK (1.00) ALKINSR
SCHEMBL20085701 0.84 ALK (0.79) ALKINSR
SCHEMBL1546061 0.84 ALK (0.73) ALKINSR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4362939-A1 BIFUNCTIONAL COMPOUNDS THAT DEGRADE ALK AND USES THEREOF Dana-Farber Cancer Institute, Inc. (US) 2024-05-08 EP disclosed
WO-2023278325-A1 BIFUNCTIONAL COMPOUNDS THAT DEGRADE ALK AND USES THEREOF DANA-FARBER CANCER INSTITUTE, INC. (US) 2023-01-05 WO disclosed