Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.49 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.46 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 11/20 | 0.44 |
| ▸ | GAK | O14976 | 1/20 | 0.44 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.44 |
| ▸ | COQ8A | Q8NI60 | 1/20 | 0.44 |
| ▸ | NLK | Q9UBE8 | 1/20 | 0.44 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.41 |
| ▸ | RAF1 | P04049 | 1/20 | 0.41 |
| ▸ | BRAF | P15056 | 1/20 | 0.41 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.40 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.39 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24004064 | 1.00 | MAPKAPK2 (0.49) | MAPKAPK2PKN1PKN2KDRGAK | |
| SCHEMBL23999401 | 0.91 | MAPKAPK2 (0.51) | MAPKAPK2KDRGAKRIPK2COQ8A | |
| SCHEMBL23999396 | 0.88 | MAPKAPK2 (0.52) | MAPKAPK2PKN1PKN2KDRGAK | |
| SCHEMBL23999513 | 0.86 | MAPKAPK2 (0.52) | MAPKAPK2PKN1PKN2KDRGAK | |
| SCHEMBL23999449 | 0.86 | MAPKAPK2 (0.52) | MAPKAPK2PKN1PKN2KDRGAK | |
| SCHEMBL23999408 | 0.86 | MAPKAPK2 (0.49) | MAPKAPK2PKN1PKN2KDRGAK | |
| SCHEMBL23999350 | 0.85 | KDR (0.59) | MAPKAPK2PKN1PKN2KDRGAK | |
| SCHEMBL23999436 | 0.85 | KDR (0.59) | MAPKAPK2PKN1PKN2KDRGAK | |
| SCHEMBL23999403 | 0.84 | LRRK2 (0.43) | MAPKAPK2PKN1PKN2KDRGAK | |
| SCHEMBL23999400 | 0.83 | MAPKAPK2 (0.43) | MAPKAPK2KDRGAKRIPK2COQ8A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4426279-A1 | AKT3 MODULATORS | Georgiamune Inc. (US) | 2024-09-11 | — | — | EP | disclosed |
| CN-118524833-A | AKT3 modulators | 乔治穆内公司 | 2024-08-20 | — | — | CN | disclosed |
| WO-2023081854-A1 | AKT3 MODULATORS | GEORGIAMUNE LLC (US) | 2023-05-11 | — | — | WO | disclosed |
| CN-115996939-A | AKT3 modulators | 乔治穆内有限责任公司 | 2023-04-21 | — | — | CN | disclosed |
| CN-115867562-A | AKT3 modulators | 乔治穆内有限责任公司 | 2023-03-28 | — | — | CN | disclosed |
| EP-4146667-A1 | AKT3 MODULATORS | Georgiamune LLC (US) | 2023-03-15 | — | — | EP | disclosed |
| EP-4146666-A1 | AKT3 MODULATORS | Georgiamune LLC (US) | 2023-03-15 | — | — | EP | disclosed |