Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 16/20 | 0.45 |
| ▸ | TCF4 | P15884 | 1/20 | 0.36 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.34 |
| ▸ | MET | P08581 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23999674 | 1.00 | KDR (0.45) | KDRTCF4CTNNB1AURKAMAPKAPK2 | |
| SCHEMBL23999675 | 0.91 | KDR (0.53) | KDRTCF4CTNNB1MAPKAPK2MET | |
| SCHEMBL30180450 | 0.91 | KDR (0.53) | KDRTCF4CTNNB1MAPKAPK2MET | |
| SCHEMBL30180305 | 0.90 | KDR (0.40) | KDRTCF4CTNNB1MAPKAPK2 | |
| SCHEMBL23999478 | 0.90 | KDR (0.40) | KDRTCF4CTNNB1MAPKAPK2 | |
| SCHEMBL23999658 | 0.89 | KDR (0.41) | KDRTCF4CTNNB1AURKA | |
| SCHEMBL30180545 | 0.89 | KDR (0.41) | KDRTCF4CTNNB1AURKA | |
| SCHEMBL23999443 | 0.87 | KDR (0.39) | KDRTCF4CTNNB1AURKANPC1 | |
| SCHEMBL30180266 | 0.87 | KDR (0.39) | KDRTCF4CTNNB1AURKANPC1 | |
| SCHEMBL23999676 | 0.85 | KDR (0.42) | KDRMAPKAPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250002511-A1 | AKT3 MODULATORS | Georgiamune Inc. | 2025-01-02 | — | — | US | disclosed |
| EP-4426279-A1 | AKT3 MODULATORS | Georgiamune Inc. (US) | 2024-09-11 | — | — | EP | disclosed |
| US-20230295114-A1 | AKT3 MODULATORS | Georgiamune Inc. | 2023-09-21 | — | — | US | disclosed |
| US-20230183226-A1 | AKT3 MODULATORS | Georgiamune Inc. | 2023-06-15 | — | — | US | disclosed |
| WO-2023081854-A1 | AKT3 MODULATORS | GEORGIAMUNE LLC (US) | 2023-05-11 | — | — | WO | disclosed |
| EP-4146666-A1 | AKT3 MODULATORS | Georgiamune LLC (US) | 2023-03-15 | — | — | EP | disclosed |
| EP-4146667-A1 | AKT3 MODULATORS | Georgiamune LLC (US) | 2023-03-15 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230295114-A1 | AKT3 MODULATORS | AKT3, AKT2, MTOR | KDR 3433/4885TCF4 2447/4885CTNNB1 1994/4885 |
| US-20230183226-A1 | AKT3 MODULATORS | AKT3, AKT2, MTOR | KDR 3271/4885TCF4 2393/4885CTNNB1 1885/4885 |
| US-20250002511-A1 | AKT3 MODULATORS | AKT3, PIK3C2A, PIK3C2B | KDR 1529/4885TCF4 3134/4885CTNNB1 2121/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.