SCHEMBL30180757

SCHEMBL30180757

CC(C)(CO[Si](C)(C)C(C)(C)C)c1cc(NC(=O)Nc2ccc(-c3cn(C4CC4)c4ncnc(N)c34)cc2F)on1

nearest known ligand 0.82

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
NEK7 Q8TDX7 20/20 0.82

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23966922 1.00 NEK7 (0.82) NEK7
SCHEMBL29484514 0.91 NEK7 (1.00) NEK7
SCHEMBL25793527 0.91 NEK7 (0.89) NEK7
SCHEMBL23966643 0.91 NEK7 (1.00) NEK7
SCHEMBL29484478 0.89 NEK7 (0.88) NEK7
SCHEMBL23966668 0.89 NEK7 (0.90) NEK7
SCHEMBL23966687 0.89 NEK7 (0.88) NEK7
SCHEMBL29484476 0.89 NEK7 (0.90) NEK7
SCHEMBL23966666 0.87 NEK7 (1.00) NEK7
SCHEMBL29484547 0.87 NEK7 (1.00) NEK7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115843272-A Inhibitors of NEK7 kinase 哈利亚治疗公司 2023-03-24 CN disclosed
EP-4146348-A1 INHIBITORS OF NEK7 KINASE Halia Therapeutics, Inc. (US) 2023-03-15 EP disclosed