Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NEK7 | Q8TDX7 | 1/20 | 0.55 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.53 |
| ▸ | RET | P07949 | 1/20 | 0.53 |
| ▸ | FLT3 | P36888 | 9/20 | 0.47 |
| ▸ | SRC | P12931 | 8/20 | 0.46 |
| ▸ | LCK | P06239 | 3/20 | 0.43 |
| ▸ | TEK | Q02763 | 2/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23966910 | 1.00 | NEK7 (0.55) | NEK7RIPK2RETFLT3SRC | |
| SCHEMBL30569295 | 0.84 | RET (0.56) | NEK7RETFLT3SRCLCK | |
| SCHEMBL29999015 | 0.83 | SRC (0.62) | RIPK2FLT3SRCLCKTEK | |
| SCHEMBL23966916 | 0.83 | SRC (0.62) | RIPK2FLT3SRCLCKTEK | |
| SCHEMBL30180780 | 0.82 | RET (0.54) | NEK7RETFLT3SRCLCK | |
| SCHEMBL23966790 | 0.82 | RET (0.54) | NEK7RETFLT3SRCLCK | |
| SCHEMBL23966781 | 0.80 | FLT3 (0.58) | RIPK2FLT3SRCLCKTEK | |
| SCHEMBL29998305 | 0.80 | FLT3 (0.58) | RIPK2FLT3SRCLCKTEK | |
| SCHEMBL20351783 | 0.79 | RIPK2 (0.61) | RIPK2FLT3SRC | |
| SCHEMBL29999024 | 0.79 | FLT3 (0.49) | RIPK2FLT3SRCLCKTEK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115843272-A | Inhibitors of NEK7 kinase | 哈利亚治疗公司 | 2023-03-24 | — | — | CN | disclosed |
| EP-4146348-A1 | INHIBITORS OF NEK7 KINASE | Halia Therapeutics, Inc. (US) | 2023-03-15 | — | — | EP | disclosed |