Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
| ▸ | L3MBTL3 | Q96JM7 | 16/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 15/20 | 0.37 |
| ▸ | MBTD1 | Q05BQ5 | 4/20 | 0.36 |
| ▸ | TP53BP1 | Q12888 | 2/20 | 0.36 |
| ▸ | L3MBTL4 | Q8NA19 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | ATR | Q13535 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20649159 | 1.00 | LRRK2 (0.38) | LRRK2L3MBTL3L3MBTL1MBTD1TP53BP1 | |
| SCHEMBL30183348 | 0.99 | LRRK2 (0.39) | LRRK2L3MBTL3L3MBTL1MBTD1TP53BP1 | |
| SCHEMBL20649153 | 0.99 | LRRK2 (0.39) | LRRK2L3MBTL3L3MBTL1MBTD1TP53BP1 | |
| SCHEMBL20649288 | 0.88 | ATR (0.49) | LRRK2L3MBTL3L3MBTL1MBTD1TP53BP1 | |
| SCHEMBL30183353 | 0.88 | ATR (0.49) | LRRK2L3MBTL3L3MBTL1MBTD1TP53BP1 | |
| SCHEMBL20649115 | 0.87 | ATR (0.49) | LRRK2L3MBTL3L3MBTL1MBTD1TP53BP1 | |
| SCHEMBL30183153 | 0.87 | ATR (0.49) | LRRK2L3MBTL3L3MBTL1MBTD1TP53BP1 | |
| SCHEMBL20649105 | 0.86 | ATR (0.52) | LRRK2L3MBTL3L3MBTL1MBTD1L3MBTL4 | |
| SCHEMBL20649285 | 0.86 | ATR (0.36) | LRRK2L3MBTL3L3MBTL1MBTD1RAB9A | |
| SCHEMBL30183433 | 0.86 | ATR (0.52) | LRRK2L3MBTL3L3MBTL1MBTD1L3MBTL4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110997678-B | Pyrazoloquinazoline derivatives as choline kinase inhibitors | 内尔维亚诺医疗科学公司 | 2023-02-21 | — | — | CN | claimed |
| CN-110997678-B | Pyrazoloquinazoline derivatives as choline kinase inhibitors | 内尔维亚诺医疗科学公司 | 2023-02-21 | — | — | CN | disclosed |