Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 17/20 | 0.71 |
| ▸ | DDB1 | Q16531 | 11/20 | 0.54 |
| ▸ | IKZF3 | Q9UKT9 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.52 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | AR | P10275 | 1/20 | 0.50 |
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23860665 | 1.00 | CRBN (0.71) | CRBNDDB1IKZF3ALDH1A1CHRM2 | |
| SCHEMBL20231154 | 0.94 | CRBN (0.74) | CRBNDDB1IKZF3ALDH1A1CHRM2 | |
| SCHEMBL30619696 | 0.90 | CRBN (0.74) | CRBNDDB1IKZF3ALDH1A1CHRM2 | |
| SCHEMBL31297121 | 0.90 | CRBN (0.71) | CRBNDDB1IKZF3ALDH1A1CHRM2 | |
| SCHEMBL24207009 | 0.90 | CRBN (0.71) | CRBNDDB1IKZF3ALDH1A1CHRM2 | |
| SCHEMBL30619732 | 0.89 | CRBN (0.70) | CRBNDDB1IKZF3ALDH1A1CHRM2 | |
| SCHEMBL23173959 | 0.88 | CRBN (0.69) | CRBNDDB1IKZF3ALDH1A1CHRM2 | |
| SCHEMBL31622233 | 0.88 | CRBN (0.69) | CRBNDDB1IKZF3ALDH1A1CHRM2 | |
| SCHEMBL25430131 | 0.88 | CRBN (0.69) | CRBNDDB1IKZF3ALDH1A1CHRM2 | |
| SCHEMBL31620768 | 0.88 | CRBN (0.69) | CRBNDDB1IKZF3ALDH1A1CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4121167-A1 | SELECTIVE MODULATORS OF MUTANT LRRK2 PROTEOLYSIS AND ASSOCIATED METHODS OF USE | Arvinas Operations, Inc. (US) | 2023-01-25 | — | — | EP | disclosed |
| CN-115605267-A | Selective modulators of mutant LRRK2 proteolysis and related methods of use | 阿维纳斯企业公司（US） | 2023-01-13 | — | — | CN | disclosed |