Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK5 | Q8IW41 | 2/20 | 0.42 |
| ▸ | PTK6 | Q13882 | 4/20 | 0.41 |
| ▸ | TTK | P33981 | 8/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.38 |
| ▸ | SYK | P43405 | 3/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22122967 | 1.00 | MAPKAPK5 (0.42) | MAPKAPK5PTK6TTKAURKBSYK | |
| SCHEMBL30172085 | 0.93 | MAPKAPK5 (0.43) | MAPKAPK5PTK6TTKAURKBSYK | |
| SCHEMBL22124394 | 0.93 | MAPKAPK5 (0.43) | MAPKAPK5PTK6TTKAURKBSYK | |
| Hydrochloric Acid SCHEMBL30171906 | 0.92 | PTK6 (0.46) | MAPKAPK5PTK6TTKAURKBSYK | |
| SCHEMBL24870964 | 0.89 | PTK6 (0.46) | MAPKAPK5PTK6TTKAURKBSYK | |
| SCHEMBL22160884 | 0.88 | MAPKAPK5 (0.43) | MAPKAPK5PTK6TTKAURKBLCK | |
| SCHEMBL22154245 | 0.88 | MAPKAPK5 (0.42) | MAPKAPK5PTK6TTKAURKBSYK | |
| SCHEMBL22125056 | 0.87 | PTK6 (0.47) | MAPKAPK5PTK6TTKAURKBSYK | |
| SCHEMBL30172074 | 0.87 | PTK6 (0.47) | MAPKAPK5PTK6TTKAURKBSYK | |
| SCHEMBL22123692 | 0.87 | MAPKAPK5 (0.43) | MAPKAPK5PTK6TTKAURKBSYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3898631-B1 | NOVEL IMIDAZOPYRAZINE DERIVATIVES AS ANTIBACTERIALS | HOFFMANN LA ROCHE (CH) | 2023-01-18 | — | — | EP | disclosed |