Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 12/20 | 0.64 |
| ▸ | AURKA | O14965 | 1/20 | 0.61 |
| ▸ | ULK1 | O75385 | 2/20 | 0.59 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.58 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.58 |
| ▸ | PTK2B | Q14289 | 2/20 | 0.58 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.58 |
| ▸ | INSR | P06213 | 1/20 | 0.58 |
| ▸ | IGF1R | P08069 | 1/20 | 0.58 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.58 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.57 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.57 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.57 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.55 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.55 |
| ▸ | JAK2 | O60674 | 1/20 | 0.55 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.55 |
| ▸ | TYK2 | P29597 | 1/20 | 0.55 |
| ▸ | KDR | P35968 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24752984 | 1.00 | PTK2 (0.64) | PTK2AURKAULK1MAPK9MAPK10 | |
| SCHEMBL28969662 | 0.89 | MAPK9 (0.58) | PTK2AURKAMAPK9MAPK10HDAC1 | |
| SCHEMBL30184147 | 0.88 | AURKA (0.78) | PTK2AURKAMAPK9MAPK10HDAC1 | |
| SCHEMBL24752709 | 0.88 | AURKA (0.78) | PTK2AURKAMAPK9MAPK10HDAC1 | |
| SCHEMBL30002225 | 0.87 | JAK2 (0.64) | PTK2AURKAULK1MAPK9MAPK10 | |
| SCHEMBL28969570 | 0.84 | ALK (0.56) | PTK2AURKAMAPK9MAPK10HDAC1 | |
| SCHEMBL24752248 | 0.84 | PTK2 (0.60) | PTK2AURKAULK1MAPK9MAPK10 | |
| SCHEMBL24752988 | 0.83 | PTK2 (0.59) | PTK2AURKAULK1MAPK9MAPK10 | |
| SCHEMBL28969574 | 0.83 | PTK2 (0.60) | PTK2AURKAULK1MAPK9MAPK10 | |
| SCHEMBL19831455 | 0.82 | AURKA (0.63) | PTK2AURKAULK1MAPK9MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116870016-B | Heteroaromatic compound and medical application thereof | 希格生科（深圳）有限公司 | 2024-05-28 | — | — | CN | disclosed |
| CN-117412981-A | Phosphine oxide derivative and preparation method and application thereof | 希格生科（深圳）有限公司 | 2024-01-16 | — | — | CN | disclosed |
| CN-116870016-A | Heteroaromatic compound and medical application thereof | 希格生科（深圳）有限公司 | 2023-10-13 | — | — | CN | disclosed |
| CN-115785154-A | Heteroaromatic ring compounds and medical use thereof | 希格生科（深圳）有限公司 | 2023-03-14 | — | — | CN | disclosed |