Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 19/20 | 0.55 |
| ▸ | PIK3CD | O00329 | 17/20 | 0.55 |
| ▸ | PIK3CG | P48736 | 14/20 | 0.55 |
| ▸ | PIK3CB | P42338 | 13/20 | 0.54 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.52 |
| ▸ | PIK3R1 | P27986 | 3/20 | 0.52 |
| ▸ | GAK | O14976 | 1/20 | 0.52 |
| ▸ | PRKACG | P22612 | 1/20 | 0.52 |
| ▸ | MTOR | P42345 | 1/20 | 0.52 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29099551 | 1.00 | PIK3CA (0.55) | PIK3CAPIK3CDPIK3CGPIK3CBPI4KB | |
| SCHEMBL29099579 | 0.92 | PIK3CA (0.54) | PIK3CAPIK3CDPIK3CGPIK3CBPI4KB | |
| SCHEMBL30185589 | 0.92 | PIK3CA (0.54) | PIK3CAPIK3CDPIK3CGPIK3CBPI4KB | |
| SCHEMBL29099614 | 0.92 | PIK3CA (0.57) | PIK3CAPIK3CDPIK3CGPIK3CBPI4KB | |
| SCHEMBL30185555 | 0.90 | PIK3CA (0.57) | PIK3CAPIK3CDPIK3CGPIK3CBPI4KB | |
| SCHEMBL29099542 | 0.90 | PIK3CA (0.57) | PIK3CAPIK3CDPIK3CGPIK3CBPI4KB | |
| SCHEMBL30185575 | 0.90 | PIK3CA (0.57) | PIK3CAPIK3CDPIK3CGPIK3CBPI4KB | |
| SCHEMBL29099569 | 0.88 | PIK3CA (0.61) | PIK3CAPIK3CDPIK3CGPIK3CBPI4KB | |
| SCHEMBL30185556 | 0.88 | PIK3CA (0.61) | PIK3CAPIK3CDPIK3CGPIK3CBPI4KB | |
| SCHEMBL29099571 | 0.86 | PIK3CG (0.72) | PIK3CAPIK3CDPIK3CGPIK3CBPIK3R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115611883-B | PI3K alpha inhibitor with double-ring structure, and preparation method and application thereof | 生物岛实验室 | 2025-03-28 | — | — | CN | disclosed |
| CN-115611883-A | PI3K alpha inhibitor with bicyclic structure and preparation method and application thereof | 生物岛实验室 | 2023-01-17 | — | — | CN | disclosed |