Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 20/20 | 0.73 |
| ▸ | GAK | O14976 | 4/20 | 0.73 |
| ▸ | BMP2K | Q9NSY1 | 4/20 | 0.73 |
| ▸ | CIT | O14578 | 3/20 | 0.73 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.73 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.73 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.73 |
| ▸ | LATS2 | Q9NRM7 | 1/20 | 0.73 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.73 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.54 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.54 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.54 |
| ▸ | JAK2 | O60674 | 1/20 | 0.54 |
| ▸ | DAPK1 | P53355 | 1/20 | 0.54 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.54 |
| ▸ | DMPK | Q09013 | 1/20 | 0.54 |
| ▸ | HIPK4 | Q8NE63 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | PRKG2 | Q13237 | 2/20 | 0.51 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24897659 | 1.00 | AAK1 (0.73) | AAK1GAKBMP2KCITMKNK1 | |
| SCHEMBL24897596 | 1.00 | AAK1 (0.73) | AAK1GAKBMP2KCITMKNK1 | |
| SCHEMBL30185632 | 1.00 | AAK1 (0.73) | AAK1GAKBMP2KCITMKNK1 | |
| SCHEMBL24897796 | 1.00 | AAK1 (0.73) | AAK1GAKBMP2KCITMKNK1 | |
| SCHEMBL30185639 | 1.00 | AAK1 (0.73) | AAK1GAKBMP2KCITMKNK1 | |
| SCHEMBL24897797 | 0.90 | AAK1 (0.73) | AAK1GAKBMP2KCITMKNK1 | |
| SCHEMBL30804940 | 0.90 | AAK1 (0.73) | AAK1GAKBMP2KCITMKNK1 | |
| SCHEMBL24897677 | 0.90 | AAK1 (0.73) | AAK1GAKBMP2KCITMKNK1 | |
| SCHEMBL30804936 | 0.90 | AAK1 (0.73) | AAK1GAKBMP2KCITMKNK1 | |
| SCHEMBL29174158 | 0.86 | AAK1 (0.55) | AAK1GAKBMP2KCITMKNK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119330877-A | Derivatives of protein arginine methyltransferase inhibitor and application thereof in medicine | 西藏海思科制药有限公司 | 2025-01-21 | — | — | CN | disclosed |
| CN-117715899-A | AAK1 inhibitors and uses thereof | 西藏海思科制药有限公司 | 2024-03-15 | — | — | CN | disclosed |
| WO-2023284838-A1 | AAK1 INHIBITOR AND USE THEREOF | 四川海思科制药有限公司 | 2023-01-19 | — | — | WO | disclosed |