Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 20/20 | 0.77 |
| ▸ | DAPK1 | P53355 | 3/20 | 0.77 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.77 |
| ▸ | BMP2K | Q9NSY1 | 3/20 | 0.77 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.77 |
| ▸ | MYLK2 | Q9H1R3 | 3/20 | 0.77 |
| ▸ | GAK | O14976 | 3/20 | 0.77 |
| ▸ | HTR2B | P41595 | 1/20 | 0.77 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.77 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.63 |
| ▸ | JAK2 | O60674 | 2/20 | 0.63 |
| ▸ | HIPK4 | Q8NE63 | 2/20 | 0.63 |
| ▸ | CIT | O14578 | 2/20 | 0.63 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.63 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.63 |
| ▸ | TLK2 | Q86UE8 | 1/20 | 0.63 |
| ▸ | STK39 | Q9UEW8 | 1/20 | 0.63 |
| ▸ | TLK1 | Q9UKI8 | 1/20 | 0.63 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.63 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30185612 | 1.00 | AAK1 (0.77) | AAK1DAPK1MKNK2BMP2KMKNK1 | |
| SCHEMBL24897635 | 1.00 | AAK1 (0.77) | AAK1DAPK1MKNK2BMP2KMKNK1 | |
| SCHEMBL24897831 | 0.88 | AAK1 (0.81) | AAK1DAPK1MKNK2BMP2KMKNK1 | |
| SCHEMBL24897689 | 0.88 | AAK1 (0.81) | AAK1DAPK1MKNK2BMP2KMKNK1 | |
| SCHEMBL30059562 | 0.87 | AAK1 (1.00) | AAK1DAPK1MKNK2BMP2KMKNK1 | |
| SCHEMBL19901194 | 0.87 | AAK1 (1.00) | AAK1DAPK1MKNK2BMP2KMKNK1 | |
| SCHEMBL17155610 | 0.87 | AAK1 (1.00) | AAK1DAPK1MKNK2BMP2KMKNK1 | |
| SCHEMBL30059578 | 0.87 | AAK1 (1.00) | AAK1DAPK1MKNK2BMP2KMKNK1 | |
| SCHEMBL17155572 | 0.87 | AAK1 (1.00) | AAK1DAPK1MKNK2BMP2KMKNK1 | |
| SCHEMBL24897630 | 0.86 | AAK1 (0.75) | AAK1DAPK1MKNK2BMP2KMKNK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023284838-A1 | AAK1 INHIBITOR AND USE THEREOF | 四川海思科制药有限公司 | 2023-01-19 | — | — | WO | disclosed |