Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KRAS | P01116 | 18/20 | 0.54 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28983555 | 1.00 | KRAS (0.54) | KRASCRBNCNR1CNR2 | |
| SCHEMBL30187246 | 0.90 | KRAS (0.51) | KRASCRBN | |
| SCHEMBL28983553 | 0.90 | KRAS (0.51) | KRASCRBN | |
| SCHEMBL19411967 | 0.89 | KRAS (0.61) | KRAS | |
| SCHEMBL30085115 | 0.89 | KRAS (0.51) | KRASCRBNCNR1CNR2 | |
| SCHEMBL21458461 | 0.89 | KRAS (0.51) | KRASCRBNCNR1CNR2 | |
| SCHEMBL21458459 | 0.89 | KRAS (0.51) | KRASCRBNCNR1CNR2 | |
| SCHEMBL24698376 | 0.87 | KRAS (0.67) | KRAS | |
| SCHEMBL29125119 | 0.87 | KRAS (0.67) | KRAS | |
| SCHEMBL30686959 | 0.87 | KRAS (0.67) | KRAS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4132655-A1 | COMPOUNDS AND METHODS FOR TARGETED DEGRADATION OF KRAS | Arvinas Operations, Inc. (US) | 2023-02-15 | — | — | EP | disclosed |