Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KRAS | P01116 | 20/20 | 0.73 |
| ▸ | VHL | P40337 | 1/20 | 0.59 |
| ▸ | CDK7 | P50613 | 1/20 | 0.59 |
| ▸ | CCNH | P51946 | 1/20 | 0.59 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.59 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20974532 | 1.00 | KRAS (0.73) | KRASVHLCDK7CCNHMNAT1 | |
| SCHEMBL21846345 | 0.94 | KRAS (0.84) | KRASVHLCDK7CCNHMNAT1 | |
| SCHEMBL20974489 | 0.94 | KRAS (0.84) | KRASVHLCDK7CCNHMNAT1 | |
| SCHEMBL21005154 | 0.92 | KRAS (0.71) | KRASVHLCDK7CCNHMNAT1 | |
| SCHEMBL21005394 | 0.91 | KRAS (0.70) | KRASVHLCDK7CCNHMNAT1 | |
| SCHEMBL21005110 | 0.91 | KRAS (0.70) | KRASVHLCDK7CCNHMNAT1 | |
| SCHEMBL20975120 | 0.91 | KRAS (0.88) | KRASVHLCDK7CCNHMNAT1 | |
| SCHEMBL20974695 | 0.91 | KRAS (0.88) | KRASVHLCDK7CCNHMNAT1 | |
| SCHEMBL22088510 | 0.91 | KRAS (0.88) | KRASVHLCDK7CCNHMNAT1 | |
| SCHEMBL20975121 | 0.91 | KRAS (0.88) | KRASVHLCDK7CCNHMNAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3710439-B1 | KRAS G12C INHIBITORS | MIRATI THERAPEUTICS INC (US) | 2023-02-15 | — | — | EP | disclosed |