Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KRAS | P01116 | 8/20 | 0.45 |
| ▸ | TLR9 | Q9NR96 | 6/20 | 0.44 |
| ▸ | TLR7 | Q9NYK1 | 4/20 | 0.44 |
| ▸ | MTOR | P42345 | 2/20 | 0.39 |
| ▸ | RAF1 | P04049 | 1/20 | 0.37 |
| ▸ | BRAF | P15056 | 1/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.36 |
| ▸ | CSF1R | P07333 | 1/20 | 0.36 |
| ▸ | KIT | P10721 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19948571 | 1.00 | KRAS (0.45) | KRASTLR9TLR7MTORRAF1 | |
| SCHEMBL19959300 | 0.94 | KRAS (0.45) | KRASTLR9TLR7MTORRAF1 | |
| SCHEMBL19637327 | 0.90 | KRAS (0.56) | KRAS | |
| SCHEMBL30188995 | 0.90 | KRAS (0.56) | KRAS | |
| SCHEMBL19637328 | 0.89 | KRAS (0.42) | KRASTLR9TLR7KIT | |
| SCHEMBL19617021 | 0.86 | KRAS (0.42) | KRASTLR9TLR7 | |
| SCHEMBL19617086 | 0.83 | KRAS (0.60) | KRAS | |
| SCHEMBL19637302 | 0.83 | KRAS (0.56) | KRAS | |
| SCHEMBL30188858 | 0.82 | KRAS (0.58) | KRAS | |
| SCHEMBL19637181 | 0.82 | KRAS (0.58) | KRAS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3710439-B1 | KRAS G12C INHIBITORS | MIRATI THERAPEUTICS INC (US) | 2023-02-15 | — | — | EP | disclosed |