Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT3 | P40763 | 4/20 | 0.67 |
| ▸ | MAP1LC3B | Q9GZQ8 | 7/20 | 0.60 |
| ▸ | CRBN | Q96SW2 | 8/20 | 0.57 |
| ▸ | IKZF3 | Q9UKT9 | 3/20 | 0.53 |
| ▸ | IKZF1 | Q13422 | 2/20 | 0.53 |
| ▸ | BRD4 | O60885 | 2/20 | 0.53 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.53 |
| ▸ | TNF | P01375 | 1/20 | 0.53 |
| ▸ | IL1B | P01584 | 1/20 | 0.53 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22789078 | 1.00 | STAT3 (0.67) | STAT3MAP1LC3BCRBNIKZF3IKZF1 | |
| SCHEMBL22773798 | 1.00 | STAT3 (0.67) | STAT3MAP1LC3BCRBNIKZF3IKZF1 | |
| SCHEMBL22788954 | 1.00 | STAT3 (0.67) | STAT3MAP1LC3BCRBNIKZF3IKZF1 | |
| SCHEMBL20933049 | 1.00 | STAT3 (0.67) | STAT3MAP1LC3BCRBNIKZF3IKZF1 | |
| SCHEMBL22789066 | 0.98 | STAT3 (0.65) | STAT3MAP1LC3BCRBNIKZF3IKZF1 | |
| SCHEMBL30189599 | 0.98 | STAT3 (0.65) | STAT3MAP1LC3BCRBNIKZF3IKZF1 | |
| SCHEMBL21294451 | 0.94 | STAT3 (0.66) | STAT3MAP1LC3BCRBNIKZF3IKZF1 | |
| SCHEMBL21332800 | 0.94 | STAT3 (0.66) | STAT3MAP1LC3BCRBNIKZF3IKZF1 | |
| SCHEMBL30996464 | 0.94 | STAT3 (0.66) | STAT3MAP1LC3BCRBNIKZF3IKZF1 | |
| SCHEMBL21303980 | 0.94 | STAT3 (0.66) | STAT3MAP1LC3BCRBNIKZF3IKZF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115611902-B | Protein degradation compound designed based on Bruton tyrosine kinase ligand and application thereof | 标新生物医药科技(上海)有限公司 | 2024-11-22 | — | — | CN | disclosed |
| WO-2023284703-A1 | PROTEIN DEGRADATION COMPOUND DESIGNED ON THE BASIS OF BRUTON'S TYROSINE KINASE LIGAND AND APPLICATION THEREOF | 标新生物医药科技(上海)有限公司 | 2023-01-19 | — | — | WO | disclosed |
| CN-115611902-A | Protein degradation compound designed based on Bruton's tyrosine kinase ligand and application thereof | 标新生物医药科技(上海)有限公司 | 2023-01-17 | — | — | CN | disclosed |