SCHEMBL30189780

SCHEMBL30189780

COc1ccc(N)c(OCc2ccccc2)c1

nearest known ligand 0.58

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
MAOB P27338 4/20 0.58
ALDH1A1 P00352 2/20 0.56
CYP3A4 P08684 1/20 0.56
ABCB1 P08183 5/20 0.54
HTR1A P08908 2/20 0.54
DRD2 P14416 2/20 0.54
HDAC8 Q9BY41 1/20 0.52
RAB9A P51151 2/20 0.50
GAA P10253 2/20 0.50
MAPT P10636 2/20 0.50
SMN1; SMN2 Q16637 2/20 0.50
NPC1 O15118 1/20 0.50
MAOA P21397 1/20 0.50
L3MBTL1 Q9Y468 1/20 0.50
ALOX12 P18054 1/20 0.48
MTNR1A P48039 1/20 0.47
MTNR1B P49286 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3915606 1.00 MAOB (0.58) MAOBALDH1A1CYP3A4ABCB1HTR1A
SCHEMBL4053551 0.88 MAOB (0.59) MAOBCYP3A4RAB9AGAAMAPT
SCHEMBL7291737 0.87 MAOB (0.58) MAOBALDH1A1CYP3A4RAB9AGAA
SCHEMBL9315251 0.87 MAOB (0.58) MAOBALDH1A1ABCB1HTR1ADRD2
SCHEMBL2992089 0.85 MAOB (0.53) MAOBALDH1A1ABCB1HTR1ADRD2
SCHEMBL30461777 0.85 MAOB (0.53) MAOBALDH1A1ABCB1HTR1ADRD2
SCHEMBL22686870 0.84 MAOB (0.56) MAOBALDH1A1CYP3A4RAB9AGAA
SCHEMBL30058080 0.84 MAOB (0.50) MAOBRAB9AGAAMAPTSMN1; SMN2
SCHEMBL647614 0.84 MAOB (0.50) MAOBRAB9AGAAMAPTSMN1; SMN2
SCHEMBL13791570 0.83 MAOB (0.62) MAOBALDH1A1ABCB1HTR1ADRD2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109689647-B Bicyclic heteroaryl substituted compounds 百时美施贵宝公司 2023-01-20 CN disclosed