Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 1/20 | 0.49 |
| ▸ | PSEN1 | P49768 | 4/20 | 0.42 |
| ▸ | PSEN2 | P49810 | 4/20 | 0.42 |
| ▸ | APH1B | Q8WW43 | 4/20 | 0.42 |
| ▸ | NCSTN | Q92542 | 4/20 | 0.42 |
| ▸ | APH1A | Q96BI3 | 4/20 | 0.42 |
| ▸ | PSENEN | Q9NZ42 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | BCHE | P06276 | 3/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | CTSL | P07711 | 1/20 | 0.38 |
| ▸ | CTSB | P07858 | 1/20 | 0.38 |
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29260410 | 1.00 | PDE4D (0.49) | PDE4DPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL21872714 | 1.00 | PDE4D (0.49) | PDE4DPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL30190032 | 1.00 | PDE4D (0.49) | PDE4DPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL29260367 | 1.00 | PDE4D (0.49) | PDE4DPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL20231391 | 1.00 | PDE4D (0.49) | PDE4DPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL24898573 | 1.00 | PDE4D (0.49) | PDE4DPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL8462243 | 0.92 | PDE4D (0.43) | PDE4DPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL21011807 | 0.83 | PDE4D (0.51) | PDE4DPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL22151309 | 0.83 | PDE4D (0.51) | PDE4DPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL25319621 | 0.83 | PDE4D (0.51) | PDE4DPSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4370523-A1 | HETEROCYCLIC COMPOUNDS AS MAP4K1 INHIBITORS | Blueprint Medicines Corporation (US) | 2024-05-22 | — | — | EP | disclosed |
| CN-117940438-A | Heterocyclic compounds as MAP4K1 inhibitors | 缆图药品公司 | 2024-04-26 | — | — | CN | disclosed |
| WO-2023288254-A1 | HETEROCYCLIC COMPOUNDS AS MAP4K1 INHIBITORS | BLUEPRINT MEDICINES CORPORATION (US) | 2023-01-19 | — | — | WO | disclosed |