⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15336501 | 1.00 | — | — | |
| SCHEMBL301923 | 1.00 | — | — | |
| Hydrochloric Acid SCHEMBL9425321 | 0.98 | — | — | |
| Hydrochloric Acid SCHEMBL9425326 | 0.98 | — | — | |
| SCHEMBL2917250 | 0.86 | — | — | |
| SCHEMBL2916007 | 0.85 | — | — | |
| Hydrochloric Acid SCHEMBL3316707 | 0.83 | HTR2C (0.31) | — | |
| SCHEMBL13778886 | 0.79 | — | — | |
| SCHEMBL30857797 | 0.77 | — | — | |
| Hydrochloric Acid SCHEMBL4182332 | 0.77 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4851085-B2 | — | — | 2012-01-11 | — | — | JP | claimed |
| EP-1532109-A1 | PYRROLIDINE DERIVATIVES AS OXYTOCIN ANTAGONISTS | Applied Research Systems ARS Holding N.V. (AN) | 2005-05-25 | — | — | EP | claimed |
| WO-2004005249-A1 | PYRROLIDINE DERIVATIVES AS OXYTOCIN ANTAGONISTS | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2004-01-15 | — | — | WO | claimed |
| CN-119233976-A | Modulators of c-MYC mRNA translation and their use in the treatment of cancer | 艾尼莫生物科技公司 | 2024-12-31 | — | — | CN | disclosed |
| US-20240228439-A1 | PYRROLIDINE DERIVATIVES AS OXYTOCIN/VASOPRESSIN V1A RECEPTORS ANTAGONISTS | ReproNovo SA (CH) | 2024-07-11 | — | — | US | disclosed |
| US-20230097933-A1 | PYRROLIDINE DERIVATIVES AS OXYTOCIN/VASOPRESSIN V1A RECEPTORS ANTAGONISTS | ReproNovo SA (CH) | 2023-03-30 | — | — | US | disclosed |
| CN-115590849-A | Oxytocin antagonist dosing regimen to promote embryo implantation and prevent miscarriage | 奥布赛瓦股份公司（CH） | 2023-01-13 | — | — | CN | disclosed |
| CN-115569132-A | Oxytocin antagonist dosing regimen to promote embryo implantation and prevent miscarriage | 奥布赛瓦股份公司 | 2023-01-06 | — | — | CN | disclosed |
| EP-4103750-A1 | BIOMARKERS FOR OXYTOCIN RECEPTOR ANTAGONIST THERAPY | ObsEva S.A. (CH) | 2022-12-21 | — | — | EP | disclosed |
| CN-109689048-B | Oxytocin antagonist dosing regimen to promote embryo implantation and prevent miscarriage | 奥布赛瓦股份公司 | 2022-10-28 | — | — | CN | disclosed |
| US-11419851-B2 | Oral formulations of pyrrolidine derivatives | ObsEva S.A. (CH) | 2022-08-23 | — | — | US | disclosed |
| CN-114105851-A | Crystals useful in methods of treating disorders associated with OT-R activity | 奥布赛瓦股份公司 | 2022-03-01 | — | — | CN | disclosed |
| WO-2017078352-A1 | CYCLOHEXENE DERIVATIVE, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING METABOLIC DISEASE COMPRISING THE SAME AS ACTIVE INGREDIENT | HYUNDAI PHARM CO., LTD. (KR) | 2017-05-11 | — | — | WO | disclosed |
| EP-3138834-A1 | CYCLOHEXENE DERIVATIVE, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING METABOLIC DISEASES, CONTAINING SAME AS ACTIVE INGREDIENT | Hyundai Pharm Co., Ltd. (KR) | 2017-03-08 | — | — | EP | disclosed |
| US-7115754-B2 | Pyrrolidine derivatives as oxytocin antagonists | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2006-10-03 | — | — | US | disclosed |
| US-20060004020-A1 | Pyrrolidine derivatives as oxytocin antagonists | MERCK SERONO SA (CH) | 2006-01-05 | — | — | US | disclosed |
| EP-1597229-A2 | PYRROLIDINE DERIVATIVES AS OXYTOCIN ANTAGONISTS | Applied Research Systems ARS Holding N.V. (AN) | 2005-11-23 | — | — | EP | disclosed |
| WO-2004076407-A2 | PYRROLIDINE DERIVATIVES AS OXYTOCIN ANTAGONISTS | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (NL) | 2004-09-10 | — | — | WO | disclosed |
| EP-1268418-A1 | PHARMACEUTICALLY ACTIVE PYRROLIDINE DERIVATIVES AS BAX INHIBITORS | Applied Research Systems ARS Holding N.V. (AN) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001074769-A1 | PHARMACEUTICALLY ACTIVE PYRROLIDINE DERIVATIVES AS BAX INHIBITORS | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2001-10-11 | — | — | WO | disclosed |