Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 19/20 | 0.62 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.58 |
| ▸ | MTOR | P42345 | 1/20 | 0.58 |
| ▸ | PRKDC | P78527 | 1/20 | 0.58 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24680492 | 1.00 | PIK3CA (0.62) | PIK3CAPIK3CBMTORPRKDCPIK3C3 | |
| SCHEMBL24908850 | 1.00 | PIK3CA (0.62) | PIK3CAPIK3CBMTORPRKDCPIK3C3 | |
| Trifluoroacetic Acid SCHEMBL29218976 | 0.95 | PIK3CA (0.57) | PIK3CAPIK3CBMTORPRKDCPIK3C3 | |
| SCHEMBL30090524 | 0.94 | PIK3CA (0.63) | PIK3CAPIK3CBMTORPRKDCPIK3C3 | |
| SCHEMBL24679226 | 0.94 | PIK3CA (0.63) | PIK3CAPIK3CBMTORPRKDCPIK3C3 | |
| SCHEMBL24679173 | 0.91 | PIK3CA (0.66) | PIK3CAPIK3CBMTORPRKDCPIK3C3 | |
| SCHEMBL30090620 | 0.90 | PIK3CA (0.60) | PIK3CAPIK3CBMTORPRKDCPIK3C3 | |
| SCHEMBL24679052 | 0.90 | PIK3CA (0.60) | PIK3CAPIK3CBMTORPRKDCPIK3C3 | |
| SCHEMBL24908863 | 0.90 | PIK3CA (0.60) | PIK3CAPIK3CBMTORPRKDCPIK3C3 | |
| SCHEMBL24680821 | 0.90 | PIK3CA (0.49) | PIK3CAPIK3CBMTORPRKDCPIK3C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4334312-A1 | ALLOSTERIC CHROMENONE INHIBITORS OF PHOSPHOINOSITIDE 3-KINASE (PI3K) FOR THE TREATMENT OF DISEASE | Petra Pharma Corporation (US) | 2024-03-13 | — | — | EP | disclosed |
| CN-117597343-A | Allosteric ketene inhibitors of phosphoinositide 3-kinase (PI 3K) for the treatment of disease | 佩特拉制药公司 | 2024-02-23 | — | — | CN | disclosed |
| WO-2022235575-A1 | ALLOSTERIC CHROMENONE INHIBITORS OF PHOSPHOINOSITIDE 3-KINASE (PI3K) FOR THE TREATMENT OF DISEASE | PETRA PHARMA CORPORATION (US) | 2022-11-10 | — | — | WO | disclosed |