Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK5 | Q8IW41 | 2/20 | 0.39 |
| ▸ | TTK | P33981 | 7/20 | 0.37 |
| ▸ | PTK6 | Q13882 | 2/20 | 0.35 |
| ▸ | EPHA2 | P29317 | 7/20 | 0.34 |
| ▸ | EPHB4 | P54760 | 5/20 | 0.34 |
| ▸ | KDR | P35968 | 5/20 | 0.34 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22123736 | 1.00 | MAPKAPK5 (0.39) | MAPKAPK5TTKPTK6EPHA2EPHB4 | |
| SCHEMBL22123261 | 0.93 | MAPKAPK5 (0.42) | MAPKAPK5TTKPTK6EPHA2EPHB4 | |
| SCHEMBL30183474 | 0.93 | MAPKAPK5 (0.42) | MAPKAPK5TTKPTK6EPHA2EPHB4 | |
| SCHEMBL22124008 | 0.91 | MAPKAPK5 (0.38) | MAPKAPK5TTKPTK6EPHA2EPHB4 | |
| SCHEMBL22122945 | 0.90 | MAPKAPK5 (0.41) | MAPKAPK5TTKPTK6EPHA2EPHB4 | |
| SCHEMBL30403346 | 0.90 | MAPKAPK5 (0.41) | MAPKAPK5TTKPTK6EPHA2EPHB4 | |
| Hydrochloric Acid SCHEMBL22123929 | 0.90 | MAPKAPK5 (0.41) | MAPKAPK5TTKPTK6EPHA2EPHB4 | |
| SCHEMBL22124850 | 0.86 | MAPKAPK5 (0.41) | MAPKAPK5TTKPTK6EPHA2EPHB4 | |
| SCHEMBL22124394 | 0.84 | MAPKAPK5 (0.43) | MAPKAPK5TTKPTK6KDRAURKB | |
| SCHEMBL30172085 | 0.84 | MAPKAPK5 (0.43) | MAPKAPK5TTKPTK6KDRAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3898630-B1 | NOVEL IMIDAZOPYRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2023-05-10 | — | — | EP | disclosed |
| EP-3898629-B1 | IMIDAZOPYRAZINE DERIVATIVES AS ANTIBACTERIALS | HOFFMANN LA ROCHE (CH) | 2023-01-18 | — | — | EP | disclosed |