Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | PSEN1 | P49768 | 4/20 | 0.52 |
| ▸ | PSEN2 | P49810 | 4/20 | 0.52 |
| ▸ | APH1B | Q8WW43 | 4/20 | 0.52 |
| ▸ | NCSTN | Q92542 | 4/20 | 0.52 |
| ▸ | APH1A | Q96BI3 | 4/20 | 0.52 |
| ▸ | PSENEN | Q9NZ42 | 4/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 2/20 | 0.42 |
| ▸ | BRAF | P15056 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.42 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | IGF1R | P08069 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3029840 | 0.94 | PSEN1 (0.54) | CYP3A4CYP2D6CYP2C9PSEN1PSEN2 | |
| SCHEMBL3028351 | 0.87 | PSEN1 (0.53) | CYP3A4CYP2D6CYP2C9PSEN1PSEN2 | |
| SCHEMBL3028364 | 0.86 | PSEN1 (0.50) | CYP3A4CYP2D6CYP2C9PSEN1PSEN2 | |
| SCHEMBL3011624 | 0.86 | PSEN1 (0.63) | CYP3A4CYP2D6CYP2C9PSEN1PSEN2 | |
| SCHEMBL3025804 | 0.85 | PSEN1 (0.51) | CYP3A4CYP2D6CYP2C9PSEN1PSEN2 | |
| SCHEMBL3018904 | 0.84 | PSEN1 (0.61) | CYP3A4CYP2D6CYP2C9PSEN1PSEN2 | |
| SCHEMBL3017611 | 0.83 | PSEN1 (0.49) | CYP3A4CYP2D6CYP2C9PSEN1PSEN2 | |
| SCHEMBL3027751 | 0.82 | PSEN1 (0.53) | CYP3A4CYP2D6CYP2C9PSEN1PSEN2 | |
| SCHEMBL3030548 | 0.81 | PSEN1 (0.53) | CYP3A4CYP2D6CYP2C9PSEN1PSEN2 | |
| SCHEMBL3023188 | 0.81 | PSEN1 (0.77) | CYP3A4CYP2D6CYP2C9PSEN1PSEN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100204230-A1 | PIPERAZINE DERIVATIVES FOR TREATMENT OF AD AND RELATED CONDITIONS | MERCK SHARP & DOHME CORP. | 2010-08-12 | — | — | US | disclosed |
| US-20100204230-A1 | PIPERAZINE DERIVATIVES FOR TREATMENT OF AD AND RELATED CONDITIONS | MERCK SHARP & DOHME CORP. | 2010-08-12 | — | — | US | disclosed |
| US-20100204230-A1 | PIPERAZINE DERIVATIVES FOR TREATMENT OF AD AND RELATED CONDITIONS | MERCK SHARP & DOHME CORP. | 2010-08-12 | — | — | US | disclosed |
| WO-2008099210-A2 | PIPERAZINE DERIVATIVES FOR TREATMENT OF AD AND RELATED CONDITIONS | MERCK & CO., INC. (US) | 2008-08-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100204230-A1 | PIPERAZINE DERIVATIVES FOR TREATMENT OF AD AND RELATED CONDITIONS | PSEN1, PSEN2, APP | CYP3A4 2378/4885CYP2D6 3553/4885CYP2C9 4188/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.