SCHEMBL30196164

SCHEMBL30196164

COCc1cccc(-c2ccc3[nH]cc(NC(=O)Nc4ccc(C(F)(F)F)cc4)c3c2)c1

nearest known ligand 0.58

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ STING1 Q86WV6 11/20 0.58
▸ TRPV1 Q8NER1 1/20 0.44
▸ GOT1 P17174 1/20 0.43
▸ IGF1R P08069 2/20 0.43
▸ MET P08581 1/20 0.43
▸ SRC P12931 1/20 0.43
▸ MGLL Q99685 1/20 0.43
▸ BAZ1A Q9NRL2 1/20 0.43
▸ MAPT P10636 2/20 0.42
▸ MEN1 O00255 1/20 0.42
▸ HTT P42858 1/20 0.42
▸ RAB9A P51151 1/20 0.42
▸ KMT2A Q03164 1/20 0.42
▸ AGXT P21549 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23208031 1.00 STING1 (0.58) STING1TRPV1GOT1IGF1RMET
SCHEMBL23207913 0.89 STING1 (0.62) STING1TRPV1GOT1IGF1RBAZ1A
SCHEMBL30195943 0.89 STING1 (0.62) STING1TRPV1GOT1IGF1RBAZ1A
SCHEMBL23207761 0.89 STING1 (0.52) STING1TRPV1GOT1IGF1R
SCHEMBL30196123 0.87 STING1 (0.58) STING1TRPV1GOT1IGF1RMAPT
SCHEMBL23207908 0.87 STING1 (0.58) STING1TRPV1GOT1IGF1RMAPT
SCHEMBL30195946 0.87 STING1 (0.60) STING1TRPV1GOT1IGF1RBAZ1A
SCHEMBL23208029 0.87 STING1 (0.60) STING1TRPV1GOT1IGF1RBAZ1A
SCHEMBL23208191 0.86 STING1 (0.61) STING1TRPV1IGF1RMAPTMEN1
SCHEMBL30195934 0.86 STING1 (0.61) STING1TRPV1IGF1RMAPTMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230002320-A1 COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY NOVARTIS PHARMA AG (CH) 2023-01-05 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230002320-A1 COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY STING1, CGAS, IRF3 STING1 1/4885TRPV1 671/4885GOT1 926/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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