Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EHMT2 | Q96KQ7 | 4/20 | 0.70 |
| ▸ | KDM1A | O60341 | 3/20 | 0.70 |
| ▸ | RCOR1 | Q9UKL0 | 3/20 | 0.70 |
| ▸ | HTT | P42858 | 3/20 | 0.53 |
| ▸ | APP | P05067 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | PDE4A | P27815 | 1/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.46 |
| ▸ | ELANE | P08246 | 1/20 | 0.45 |
| ▸ | EGFR | P00533 | 7/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | RAF1 | P04049 | 1/20 | 0.44 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.43 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18103418 | 1.00 | EHMT2 (0.70) | EHMT2KDM1ARCOR1HTTAPP | |
| SCHEMBL18103392 | 0.83 | EHMT2 (0.64) | EHMT2KDM1ARCOR1EZH2KMT5A | |
| SCHEMBL30197751 | 0.83 | EHMT2 (0.64) | EHMT2KDM1ARCOR1EZH2KMT5A | |
| SCHEMBL20266987 | 0.79 | APP (0.71) | HTTAPPMAPK1PDE4APDE4B | |
| SCHEMBL31620285 | 0.77 | MAPK1 (0.62) | EHMT2KDM1ARCOR1HTTAPP | |
| SCHEMBL29384944 | 0.77 | ELANE (0.55) | EHMT2KDM1AHTTELANEEGFR | |
| SCHEMBL1940198 | 0.77 | ELANE (0.55) | EHMT2KDM1AHTTELANEEGFR | |
| SCHEMBL2063141 | 0.77 | ELANE (0.55) | EHMT2KDM1AHTTELANEEGFR | |
| SCHEMBL3643238 | 0.77 | EGFR (0.65) | HTTAPPMAPK1PDE4APDE4B | |
| SCHEMBL6766790 | 0.75 | ABCB1 (0.56) | KDM1AELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3277676-B1 | SUBSTITUTED QUINAZOLINE DERIVATIVES AS DNA METHYLTRANSFERASE INHIBITORS | PF MEDICAMENT (FR) | 2023-03-22 | — | — | EP | disclosed |