Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.62 |
| ▸ | LMNA | P02545 | 4/20 | 0.62 |
| ▸ | MEN1 | O00255 | 4/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.62 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.62 |
| ▸ | GAA | P10253 | 1/20 | 0.62 |
| ▸ | CRHBP | P24387 | 1/20 | 0.62 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 5/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | ALPL | P05186 | 8/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | TNF | P01375 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23833708 | 1.00 | KMT2A (0.62) | KMT2ALMNAMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL25757169 | 0.81 | KMT2A (0.65) | KMT2ALMNAMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL25755588 | 0.80 | MAPT (0.67) | KMT2ALMNAMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL23846438 | 0.80 | KMT2A (0.62) | KMT2ALMNAMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL25755498 | 0.80 | KMT2A (0.62) | KMT2ALMNAMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL23846671 | 0.79 | MAPT (0.60) | KMT2ALMNAMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL17980878 | 0.79 | KMT2A (0.61) | KMT2ALMNAMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL29395779 | 0.79 | KMT2A (0.61) | KMT2ALMNAMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL25755504 | 0.79 | MAPT (0.82) | KMT2ALMNAMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL25755495 | 0.78 | MAPT (0.67) | KMT2ALMNAMEN1ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4121029-A1 | BENZENESULFONAMIDE DERIVATIVES AS TRAP1 MODULATORS AND USES THEREOF | Amathus Therapeutics, Inc. (US) | 2023-01-25 | — | — | EP | disclosed |