Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 18/20 | 1.00 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.86 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.86 |
| ▸ | ABCC4 | O15439 | 2/20 | 0.86 |
| ▸ | PDE2A | O00408 | 1/20 | 0.86 |
| ▸ | ABCC5 | O15440 | 1/20 | 0.86 |
| ▸ | PDE6D | O43924 | 1/20 | 0.86 |
| ▸ | PDE8A | O60658 | 1/20 | 0.86 |
| ▸ | PDE9A | O76083 | 1/20 | 0.86 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.86 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.86 |
| ▸ | HTR1A | P08908 | 1/20 | 0.86 |
| ▸ | PDE6A | P16499 | 1/20 | 0.86 |
| ▸ | PDE6G | P18545 | 1/20 | 0.86 |
| ▸ | PDE4A | P27815 | 1/20 | 0.86 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.86 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.86 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.86 |
| ▸ | PDE6B | P35913 | 1/20 | 0.86 |
| ▸ | PDE6C | P51160 | 1/20 | 0.86 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1141 | 1.00 | PDE5A (1.00) | PDE5APDE3BPDE3AABCC4PDE2A | |
| SCHEMBL14836841 | 0.97 | PDE5A (0.94) | PDE5APDE3BPDE3AABCC4PDE2A | |
| SCHEMBL30848678 | 0.95 | PDE5A (0.95) | PDE5APDE3BPDE3AABCC4PDE2A | |
| SCHEMBL997 | 0.94 | PDE5A (0.89) | PDE5APDE3BPDE3AABCC4PDE2A | |
| SCHEMBL24430033 | 0.94 | PDE5A (0.89) | PDE5APDE3BPDE3AABCC4PDE2A | |
| SCHEMBL25118239 | 0.94 | PDE5A (0.88) | PDE5APDE3BPDE3AABCC4PDE2A | |
| SCHEMBL28415489 | 0.93 | PDE5A (0.88) | PDE5APDE3BPDE3AABCC4PDE2A | |
| Sildenafil SCHEMBL5683880 | 0.93 | PDE5A (1.00) | PDE5APDE3BPDE3AABCC4PDE2A | |
| Sildenafil SCHEMBL1895 | 0.93 | PDE5A (1.00) | PDE5APDE3BPDE3AABCC4PDE2A | |
| Sildenafil SCHEMBL29361663 | 0.93 | PDE5A (1.00) | PDE5APDE3BPDE3AABCC4PDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-120025295-A | Difluoromethyl and amino substituted olefin compound and synthesis method thereof | 浙江师范大学 | 2025-05-23 | — | — | CN | disclosed |
| CN-117890459-B | Quick screening method for illegally adding chemical drugs into foods based on MSRIT-MS/MS | 南京市食品药品监督检验院 | 2024-10-18 | — | — | CN | disclosed |
| US-20230348470-A1 | GUT-TARGETED PHOSPHODIESTERASE INHIBITORS | AUGUSTA UNIVERSITY RESEARCH INSTITUTE, INC. (US) | 2023-11-02 | — | — | US | disclosed |
| CN-115598338-A | Colloidal gold test strip for detecting PDE-5 inhibitor and preparation method and application thereof | 广东省药品检验所（广东省药品质量研究所、广东省口岸药品检验所）（CN） | 2023-01-13 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230348470-A1 | GUT-TARGETED PHOSPHODIESTERASE INHIBITORS | PDE5A, PDE2A, PDE12 | PDE5A 1/4885PDE3B 6/4885PDE3A 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.