Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 12/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | ALPL | P05186 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.49 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.49 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.49 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.49 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23833747 | 1.00 | IDH1 (0.55) | IDH1MEN1MAPTKMT2AGAA | |
| SCHEMBL25755201 | 0.85 | IDH1 (0.57) | IDH1MEN1MAPTKMT2AGAA | |
| SCHEMBL23846615 | 0.84 | MEN1 (0.52) | IDH1MEN1MAPTKMT2AGAA | |
| SCHEMBL23846387 | 0.80 | PTPN2 (0.59) | IDH1MEN1MAPTKMT2AGAA | |
| SCHEMBL23846390 | 0.79 | MAPT (0.62) | IDH1MEN1MAPTKMT2AGAA | |
| SCHEMBL25757314 | 0.78 | PTPN2 (0.57) | IDH1MEN1MAPTKMT2AGAA | |
| SCHEMBL23846617 | 0.78 | MAPT (0.56) | IDH1MEN1MAPTKMT2AGAA | |
| SCHEMBL23846622 | 0.78 | MEN1 (0.53) | IDH1MEN1MAPTKMT2AGAA | |
| SCHEMBL30199611 | 0.78 | MAPT (0.53) | IDH1MEN1MAPTKMT2AGAA | |
| SCHEMBL23833746 | 0.78 | MAPT (0.53) | IDH1MEN1MAPTKMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4121029-A1 | BENZENESULFONAMIDE DERIVATIVES AS TRAP1 MODULATORS AND USES THEREOF | Amathus Therapeutics, Inc. (US) | 2023-01-25 | — | — | EP | disclosed |