Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.44 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.39 |
| ▸ | VNN1 | O95497 | 2/20 | 0.39 |
| ▸ | MGLL | Q99685 | 4/20 | 0.38 |
| ▸ | PDE2A | O00408 | 2/20 | 0.37 |
| ▸ | NOS1 | P29475 | 1/20 | 0.36 |
| ▸ | NOS2 | P35228 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | TYK2 | P29597 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | TACR3 | P29371 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.34 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30202246 | 0.90 | HPGD (0.44) | HPGDVNN1MGLLNOS1NOS2 | |
| SCHEMBL30201251 | 0.88 | HPGD (0.48) | HPGDVNN1MGLLNOS1NOS2 | |
| SCHEMBL24942866 | 0.85 | HPGD (0.52) | HPGDGLRA1VNN1MGLLPDE2A | |
| SCHEMBL29257197 | 0.85 | HPGD (0.52) | HPGDGLRA1VNN1MGLLPDE2A | |
| SCHEMBL30201633 | 0.85 | HPGD (0.45) | HPGDGLRA1VNN1MGLLDGAT1 | |
| SCHEMBL30202213 | 0.83 | HPGD (0.42) | HPGDGLRA1VNN1MGLLPDE2A | |
| SCHEMBL23680752 | 0.83 | HPGD (0.63) | HPGDMGLLNOS1NOS2ADORA2A | |
| SCHEMBL30201388 | 0.80 | HPGD (0.41) | HPGDGLRA1VNN1MGLLPDE2A | |
| SCHEMBL24942867 | 0.80 | HPGD (0.55) | HPGDGLRA1VNN1MGLLPDE2A | |
| SCHEMBL29257202 | 0.80 | HPGD (0.55) | HPGDGLRA1VNN1MGLLPDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118338902-A | Pyrrolo [2,3-b ] pyridine PGDH inhibitors and methods of making and using the same | 埃皮里姆生物股份有限公司 | 2024-07-12 | — | — | CN | disclosed |
| EP-4376841-A1 | PYRROLO[2,3-B]PYRIDINE PGDH INHIBITORS AND METHODS OF MAKING AND USING | Epirium Bio Inc. (US) | 2024-06-05 | — | — | EP | disclosed |
| WO-2023009642-A1 | PYRROLO[2,3-B]PYRIDINE PGDH INHIBITORS AND METHODS OF MAKING AND USING | EPIRIUM BIO INC. (US) | 2023-02-02 | — | — | WO | disclosed |