Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP17A1 | P05093 | 4/20 | 0.45 |
| ▸ | NAMPT | P43490 | 2/20 | 0.43 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.43 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 2/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | TOP2A | P11388 | 1/20 | 0.38 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.38 |
| ▸ | ATR | Q13535 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24951504 | 1.00 | CYP17A1 (0.45) | CYP17A1NAMPTCYP11B1CYP11B2HSP90AB1 | |
| SCHEMBL15972019 | 0.85 | CYP17A1 (0.48) | CYP17A1NAMPTPTGDR2MAPK14TOP2A | |
| SCHEMBL30530906 | 0.85 | CYP17A1 (0.48) | CYP17A1NAMPTPTGDR2MAPK14TOP2A | |
| SCHEMBL18072998 | 0.83 | NAMPT (0.48) | CYP17A1NAMPTPTGDR2MAPK14TOP2A | |
| SCHEMBL14428036 | 0.82 | NAMPT (0.54) | CYP17A1NAMPTMAPK14TOP2ATOP2B | |
| SCHEMBL17916740 | 0.81 | CYP17A1 (0.45) | CYP17A1NAMPTPPARGPPARAMAPK14 | |
| SCHEMBL30530861 | 0.81 | CYP17A1 (0.45) | CYP17A1NAMPTPTGDR2MAPK14TOP2A | |
| SCHEMBL20382968 | 0.80 | HSP90AB1 (0.44) | CYP17A1HSP90AB1PPARGPPARALMNA | |
| SCHEMBL23592977 | 0.80 | AURKA (0.47) | CYP17A1PPARGLMNAMAPTSMN1; SMN2 | |
| SCHEMBL30489985 | 0.80 | AURKA (0.47) | CYP17A1PPARGLMNAMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4376845-A1 | PYRAZOLOPYRIMIDINES AND THEIR USES AS PDGFR INHIBITORS | Actelion Pharmaceuticals Ltd (CH) | 2024-06-05 | — | — | EP | disclosed |
| WO-2023007009-A1 | PYRAZOLOPYRIMIDINES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2023-02-02 | — | — | WO | disclosed |