Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 20/20 | 0.79 |
| ▸ | IDH2 | P48735 | 17/20 | 0.79 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20289618 | 0.94 | IDH1 (0.82) | IDH1IDH2 | |
| Crelosidenib SCHEMBL29765374 | 0.88 | IDH1 (1.00) | IDH1IDH2 | |
| Crelosidenib SCHEMBL29427547 | 0.88 | IDH1 (1.00) | IDH1IDH2 | |
| Crelosidenib SCHEMBL20270338 | 0.88 | IDH1 (1.00) | IDH1IDH2 | |
| Crelosidenib SCHEMBL20289768 | 0.88 | IDH1 (1.00) | IDH1IDH2 | |
| Crelosidenib SCHEMBL20270341 | 0.88 | IDH1 (1.00) | IDH1IDH2 | |
| Crelosidenib SCHEMBL20271764 | 0.88 | IDH1 (1.00) | IDH1IDH2 | |
| Crelosidenib SCHEMBL21799142 | 0.86 | IDH1 (0.94) | IDH1IDH2 | |
| SCHEMBL22591188 | 0.86 | IDH1 (0.81) | IDH1IDH2 | |
| SCHEMBL24170447 | 0.86 | IDH1 (0.94) | IDH1IDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11746115-B2 | Solid forms of 7-[[(1S)-1-[4-[(1S)-2-cyclopropyl-1-(4-prop-2-enoylpiperazin-1-yl)ethyl]phenyl]ethyl]amino]-1-ethyl-4H-pyrimido[4,5-d][1,3]oxazin-2-one | ELI LILLY AND COMPANY (US) | 2023-09-05 | — | — | US | disclosed |
| US-20230061806-A1 | SOLID FORMS OF 7-[[(1S)-1-[4-[(1S)-2-CYCLOPROPYL-1-(4-PROP-2-ENOYLPIPERAZIN-1-YL)ETHYL]PHENYL]ETHYL]AMINO]-1-ETHYL-4H-PYRIMIDO[4,5-D][1,3]OXAZIN-2-ONE | CURIA INDIANA, LLC | 2023-03-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11746115-B2 | Solid forms of 7-[[(1S)-1-[4-[(1S)-2-cyclopropyl-1-(4-prop-2-enoylpiperazin-1-yl)ethyl]phenyl]ethyl]amino]-1-ethyl-4H-pyrimido[4,5-d][1,3]oxazin-2-one | H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, VHL, CYP24A1 | IDH1 250/4885IDH2 561/4885 |
| US-20230061806-A1 | SOLID FORMS OF 7-[[(1S)-1-[4-[(1S)-2-CYCLOPROPYL-1-(4-PROP-2-ENOYLPIPERAZIN-1-YL)ETHYL]PHENYL]ETHYL]AMINO]-1-ETHYL-4H-PYRIMIDO[4,5-D][1,3]OXAZIN-2-ONE | H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, VHL, CYP24A1 | IDH1 250/4885IDH2 561/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.