SCHEMBL30207908

SCHEMBL30207908

Cc1ncnc2c1ccn2[C@@H]1C[C@H](C(O)c2ccc(F)cc2)[C@H]2OC(C)(C)O[C@H]21

nearest known ligand 0.47

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
▸ PRMT5 O14744 20/20 0.47
▸ WDR77 Q9BQA1 19/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19667499 1.00 PRMT5 (0.47) PRMT5WDR77
SCHEMBL19667463 0.90 PRMT5 (0.39) PRMT5WDR77
SCHEMBL30207835 0.90 PRMT5 (0.39) PRMT5WDR77
SCHEMBL30207984 0.87 PRMT5 (0.47) PRMT5WDR77
SCHEMBL19667089 0.87 PRMT5 (0.47) PRMT5WDR77
SCHEMBL19667677 0.87 PRMT5 (0.47) PRMT5WDR77
SCHEMBL19667088 0.87 PRMT5 (0.47) PRMT5WDR77
SCHEMBL30207946 0.87 PRMT5 (0.47) PRMT5WDR77
SCHEMBL19667685 0.86 PRMT5 (0.39) PRMT5WDR77
SCHEMBL20487809 0.83 PRMT5 (0.56) PRMT5WDR77

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109890797-B Substituted carbon nucleoside derivatives useful as anticancer agents 辉瑞公司 2023-02-28 — — CN disclosed
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