Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 9/20 | 0.53 |
| ▸ | CCNE1 | P24864 | 8/20 | 0.53 |
| ▸ | CDK9 | P50750 | 5/20 | 0.53 |
| ▸ | CDK7 | P50613 | 16/20 | 0.50 |
| ▸ | CCNH | P51946 | 7/20 | 0.46 |
| ▸ | CDK1 | P06493 | 6/20 | 0.46 |
| ▸ | MNAT1 | P51948 | 6/20 | 0.46 |
| ▸ | CDK4 | P11802 | 4/20 | 0.46 |
| ▸ | CDK6 | Q00534 | 4/20 | 0.46 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.46 |
| ▸ | CDK8 | P49336 | 3/20 | 0.46 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.46 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.46 |
| ▸ | CCND1 | P24385 | 2/20 | 0.46 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.46 |
| ▸ | INSRR | P14616 | 1/20 | 0.45 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24963424 | 1.00 | CDK2 (0.53) | CDK2CCNE1CDK9CDK7CCNH | |
| SCHEMBL1368924 | 0.85 | CDK7 (0.67) | CDK2CCNE1CDK9CDK7CCNH | |
| SCHEMBL24962497 | 0.85 | CDK7 (0.46) | CDK2CCNE1CDK9CDK7CCNH | |
| SCHEMBL30209116 | 0.84 | CDK7 (0.51) | CDK2CCNE1CDK9CDK7CCNH | |
| SCHEMBL24962532 | 0.84 | CDK7 (0.51) | CDK2CCNE1CDK9CDK7CCNH | |
| SCHEMBL24963255 | 0.82 | CDK7 (0.42) | CDK2CCNE1CDK9CDK7CCNH | |
| SCHEMBL30209128 | 0.82 | CDK7 (0.42) | CDK2CCNE1CDK9CDK7CCNH | |
| SCHEMBL30209126 | 0.82 | CDK7 (0.42) | CDK2CCNE1CDK9CDK7CCNH | |
| SCHEMBL1370667 | 0.82 | CDK7 (0.66) | CDK2CCNE1CDK9CDK7CCNH | |
| SCHEMBL12143379 | 0.80 | CDK7 (0.46) | CDK2CCNE1CDK9CDK7CCNH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023001061-A1 | CDK7 SELECTIVE INHIBITORS AS ANTICANCER AGENTS | JINGRUI BIOPHARMA CO., LTD. (CN) | 2023-01-26 | — | — | WO | disclosed |