Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | THRB | P10828 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | UHRF1 | Q96T88 | 2/20 | 0.41 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.41 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.41 |
| ▸ | TERT | O14746 | 3/20 | 0.40 |
| ▸ | DOT1L | Q8TEK3 | 2/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23999556 | 1.00 | HDAC3 (0.43) | HDAC3HDAC1HDAC2HDAC6CYP3A4 | |
| SCHEMBL23999529 | 0.84 | RAD52 (0.57) | HDAC3HDAC1HDAC2HDAC6CYP3A4 | |
| SCHEMBL30180617 | 0.84 | RAD52 (0.57) | HDAC3HDAC1HDAC2HDAC6CYP3A4 | |
| SCHEMBL17621230 | 0.81 | SCN9A (0.51) | HDAC3HDAC1HDAC2HDAC6UHRF1 | |
| SCHEMBL23999851 | 0.79 | HDAC3 (0.44) | HDAC3HDAC1HDAC2HDAC6UHRF1 | |
| SCHEMBL25826336 | 0.79 | TSHR (0.50) | HDAC3HDAC1HDAC2HDAC6CYP3A4 | |
| SCHEMBL24004058 | 0.77 | KDM4E (0.56) | HDAC3HDAC1HDAC2HDAC6TDP1 | |
| SCHEMBL23999510 | 0.77 | RAD52 (0.63) | CYP3A4THRBALOX15TDP1ALDH1A1 | |
| SCHEMBL23999879 | 0.77 | DOT1L (0.45) | HDAC3HDAC1HDAC2HDAC6UHRF1 | |
| SCHEMBL16538491 | 0.76 | HDAC3 (0.41) | HDAC3HDAC1HDAC2HDAC6UHRF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118524833-A | AKT3 modulators | 乔治穆内公司 | 2024-08-20 | — | — | CN | disclosed |
| CN-115996939-A | AKT3 modulators | 乔治穆内有限责任公司 | 2023-04-21 | — | — | CN | disclosed |
| CN-115867562-A | AKT3 modulators | 乔治穆内有限责任公司 | 2023-03-28 | — | — | CN | disclosed |
| EP-4146666-A1 | AKT3 MODULATORS | Georgiamune LLC (US) | 2023-03-15 | — | — | EP | disclosed |