Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | CDK5 | Q00535 | 7/20 | 0.42 |
| ▸ | CDK5R1 | Q15078 | 7/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 5/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | XIAP | P98170 | 1/20 | 0.34 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23930561 | 1.00 | SMN1; SMN2 (0.44) | SMN1; SMN2CDK5CDK5R1NPC1RAB9A | |
| SCHEMBL23930513 | 0.90 | SMN1; SMN2 (0.42) | SMN1; SMN2CDK5CDK5R1NPC1RAB9A | |
| SCHEMBL30210824 | 0.90 | SMN1; SMN2 (0.42) | SMN1; SMN2CDK5CDK5R1NPC1RAB9A | |
| SCHEMBL30210967 | 0.88 | SMN1; SMN2 (0.42) | SMN1; SMN2CDK5CDK5R1NPC1RAB9A | |
| SCHEMBL23930524 | 0.88 | SMN1; SMN2 (0.42) | SMN1; SMN2CDK5CDK5R1NPC1RAB9A | |
| SCHEMBL23930506 | 0.86 | TDP1 (0.49) | SMN1; SMN2CDK5CDK5R1NPC1RAB9A | |
| SCHEMBL30210896 | 0.86 | TDP1 (0.49) | SMN1; SMN2CDK5CDK5R1NPC1RAB9A | |
| SCHEMBL23930498 | 0.86 | MAPT (0.38) | SMN1; SMN2CDK5CDK5R1NPC1RAB9A | |
| SCHEMBL30210848 | 0.86 | MAPT (0.38) | SMN1; SMN2CDK5CDK5R1NPC1RAB9A | |
| SCHEMBL23930521 | 0.85 | SMN1; SMN2 (0.39) | SMN1; SMN2CDK5CDK5R1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115697979-B | Substituted aminothiazoles as DGKZETA inhibitors for immune activation | 拜耳公司 | 2025-06-24 | — | — | CN | claimed |
| EP-4139287-B1 | SUBSTITUTED AMINOTHIAZOLES AS DGKZETA INHIBITORS FOR IMMUNE ACTIVATION | BAYER AG (DE) | 2025-02-26 | — | — | EP | claimed |
| EP-4139287-A1 | SUBSTITUTED AMINOTHIAZOLES AS DGKZETA INHIBITORS FOR IMMUNE ACTIVATION | Bayer Aktiengesellschaft (DE) | 2023-03-01 | — | — | EP | claimed |
| EP-4139287-B1 | SUBSTITUTED AMINOTHIAZOLES AS DGKZETA INHIBITORS FOR IMMUNE ACTIVATION | BAYER AG (DE) | 2025-02-26 | — | — | EP | disclosed |