Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 17/20 | 0.67 |
| ▸ | KDR | P35968 | 15/20 | 0.67 |
| ▸ | SRC | P12931 | 14/20 | 0.67 |
| ▸ | LYN | P07948 | 13/20 | 0.67 |
| ▸ | INSR | P06213 | 12/20 | 0.67 |
| ▸ | HCK | P08631 | 10/20 | 0.67 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.54 |
| ▸ | TYK2 | P29597 | 1/20 | 0.54 |
| ▸ | SYK | P43405 | 1/20 | 0.54 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.54 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.54 |
| ▸ | JAK3 | P52333 | 1/20 | 0.54 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.54 |
| ▸ | BTK | Q06187 | 1/20 | 0.54 |
| ▸ | BRAF | P15056 | 2/20 | 0.54 |
| ▸ | RAF1 | P04049 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3004654 | 0.96 | LCK (0.67) | LCKKDRSRCLYNINSR | |
| SCHEMBL3005151 | 0.95 | LCK (0.67) | LCKKDRSRCLYNINSR | |
| SCHEMBL3004159 | 0.93 | LCK (0.76) | LCKKDRSRCLYNINSR | |
| SCHEMBL13267878 | 0.90 | LCK (0.55) | LCKKDRSRCLYNINSR | |
| SCHEMBL3021259 | 0.90 | LCK (0.54) | LCKKDRSRCLYNINSR | |
| SCHEMBL3016004 | 0.90 | LCK (0.76) | LCKKDRSRCLYNINSR | |
| SCHEMBL1833165 | 0.89 | LCK (0.66) | LCKKDRSRCLYNINSR | |
| SCHEMBL3020614 | 0.89 | BRAF (0.60) | LCKKDRSRCLYNINSR | |
| SCHEMBL3014651 | 0.89 | LCK (0.69) | LCKKDRSRCLYNINSR | |
| SCHEMBL3009202 | 0.89 | RAF1 (0.57) | LCKKDRSRCLYNINSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100184765-A1 | Protein Kinase Inhibitors and Methods for Using Thereof | IRM LLC | 2010-07-22 | — | — | US | claimed |
| EP-2170867-A1 | PROTEIN KINASE INHIBITORS AND METHODS FOR USING THEREOF | IRM LLC (BM) | 2010-04-07 | — | — | EP | claimed |
| WO-2008157131-A1 | PROTEIN KINASE INHIBITORS AND METHODS FOR USING THEREOF | IRM LLC (BM) | 2008-12-24 | — | — | WO | claimed |
| US-20100184765-A1 | Protein Kinase Inhibitors and Methods for Using Thereof | IRM LLC | 2010-07-22 | — | — | US | disclosed |
| US-20100184765-A1 | Protein Kinase Inhibitors and Methods for Using Thereof | IRM LLC | 2010-07-22 | — | — | US | disclosed |
| EP-2170867-A1 | PROTEIN KINASE INHIBITORS AND METHODS FOR USING THEREOF | IRM LLC (BM) | 2010-04-07 | — | — | EP | disclosed |
| WO-2008157131-A1 | PROTEIN KINASE INHIBITORS AND METHODS FOR USING THEREOF | IRM LLC (BM) | 2008-12-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100184765-A1 | Protein Kinase Inhibitors and Methods for Using Thereof | BMX, FRK, FYN | LCK 8/4885KDR 182/4885SRC 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.