Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.97 |
| ▸ | IL1RN | P18510 | 1/20 | 0.97 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.77 |
| ▸ | HTT | P42858 | 2/20 | 0.77 |
| ▸ | LMNA | P02545 | 2/20 | 0.77 |
| ▸ | TSHR | P16473 | 2/20 | 0.77 |
| ▸ | GAA | P10253 | 3/20 | 0.76 |
| ▸ | NPC1 | O15118 | 1/20 | 0.76 |
| ▸ | RAB9A | P51151 | 1/20 | 0.76 |
| ▸ | APEX1 | P27695 | 1/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.69 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.67 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.65 |
| ▸ | MEN1 | O00255 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.65 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.65 |
| ▸ | THRB | P10828 | 1/20 | 0.65 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1001537 | 1.00 | MAPT (0.97) | MAPTIL1RNSMN1; SMN2HTTLMNA | |
| SCHEMBL4251683 | 1.00 | MAPT (0.97) | MAPTIL1RNSMN1; SMN2HTTLMNA | |
| SCHEMBL1001486 | 0.98 | MAPT (1.00) | MAPTIL1RNSMN1; SMN2HTTLMNA | |
| SCHEMBL29463849 | 0.98 | MAPT (1.00) | MAPTIL1RNSMN1; SMN2HTTLMNA | |
| SCHEMBL3932198 | 0.95 | MAPT (0.94) | MAPTIL1RNSMN1; SMN2HTTLMNA | |
| SCHEMBL19002726 | 0.86 | SMN1; SMN2 (0.75) | MAPTIL1RNSMN1; SMN2HTTLMNA | |
| SCHEMBL14507610 | 0.86 | GAA (1.00) | MAPTIL1RNSMN1; SMN2HTTLMNA | |
| SCHEMBL19002721 | 0.86 | SMN1; SMN2 (0.75) | MAPTIL1RNSMN1; SMN2HTTLMNA | |
| SCHEMBL17911174 | 0.86 | MAPT (0.78) | MAPTIL1RNSMN1; SMN2HTTLMNA | |
| SCHEMBL3824747 | 0.85 | MAPT (0.76) | MAPTIL1RNLMNAGAANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119241504-A | Spiroindoline inhibitors of KIF18A | 沃拉斯查疗法公司 | 2025-01-03 | — | — | CN | disclosed |
| WO-2024178255-A1 | SOLID FORMULATIONS AND POLYMORPHIC FORMS OF INDOLINE INHIBITORS OF KIF18A | VOLASTRA THERAPEUTICS, INC. (US) | 2024-08-29 | — | — | WO | disclosed |
| EP-4392407-A1 | SPIRO INDOLINE INHIBITORS OF KIF18A | Volastra Therapeutics, Inc. (US) | 2024-07-03 | — | — | EP | disclosed |
| CN-118103352-A | Spiroindoline inhibitors of KIF18A | 沃拉斯查疗法公司 | 2024-05-28 | — | — | CN | disclosed |
| WO-2023028564-A1 | SPIRO INDOLINE INHIBITORS OF KIF18A | VOLASTRA THERAPEUTICS, INC. (US) | 2023-03-02 | — | — | WO | disclosed |