Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 13/20 | 0.49 |
| ▸ | KDR | P35968 | 3/20 | 0.49 |
| ▸ | KIT | P10721 | 2/20 | 0.47 |
| ▸ | BRAF | P15056 | 2/20 | 0.47 |
| ▸ | RAF1 | P04049 | 1/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.47 |
| ▸ | TEK | Q02763 | 1/20 | 0.47 |
| ▸ | MAP3K8 | P41279 | 3/20 | 0.46 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.46 |
| ▸ | SRC | P12931 | 2/20 | 0.46 |
| ▸ | PRKD1 | Q15139 | 2/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.46 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.46 |
| ▸ | PRKCG | P05129 | 1/20 | 0.46 |
| ▸ | PRKCB | P05771 | 1/20 | 0.46 |
| ▸ | PRKCA | P17252 | 1/20 | 0.46 |
| ▸ | PRKCH | P24723 | 1/20 | 0.46 |
| ▸ | PRKCI | P41743 | 1/20 | 0.46 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30213751 | 0.94 | EGFR (0.49) | EGFRKDRKITBRAFRAF1 | |
| SCHEMBL28539842 | 0.89 | AXL (0.48) | EGFRKDRBRAFMAP3K8ERBB2 | |
| SCHEMBL30213708 | 0.82 | EGFR (0.57) | EGFRERBB2 | |
| SCHEMBL30213765 | 0.81 | EGFR (0.54) | EGFRKDRKITBRAFMAP3K8 | |
| SCHEMBL30213757 | 0.81 | EGFR (0.55) | EGFRERBB2ERBB4ERBB3KCNH2 | |
| SCHEMBL30213670 | 0.80 | EGFR (0.54) | EGFRKDRKITBRAFPDGFRB | |
| SCHEMBL30213815 | 0.79 | EGFR (0.50) | EGFRERBB2ERBB4ERBB3SLC6A3 | |
| SCHEMBL30213605 | 0.78 | EGFR (0.45) | EGFRKDRKITBRAFRAF1 | |
| SCHEMBL30213685 | 0.78 | EGFR (0.60) | EGFRERBB2 | |
| SCHEMBL28543192 | 0.75 | KDR (0.39) | KDRBRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112574177-B | Pyrimidine derivatives and application thereof in preparing antitumor drugs | 陕西师范大学 | 2023-01-31 | — | — | CN | disclosed |